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SUMMARY:BioE COLLOQUIA SERIES: Reconstructing Development and Regeneration
  Using Single-Cell Genomics
DTSTART:20191111T121500
DTSTAMP:20260502T134521Z
UID:b9815355ec3e6cc977cac3bcc1832af15b98f044b12b6c3717a95978
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Barbara Treutlein\, ETH Zürich\, Department of Biosyste
 ms Science and Engineering\, Basel (CH)\nWEEKLY BIOENGINEERING COLLOQUIA S
 ERIES\n(sandwiches served)\n\nAbstract: \nIn biology\, there are many scen
 arios where cells transit from one cell state or identity to another. Duri
 ng development\, stem cells make fate decisions and differentiate into var
 ious mature cell types within a complex organ. During regeneration\, diffe
 rentiated cells can acquire a stem cell state and re-differentiate along m
 ultiple lineages. Single-cell genomics methods have proven to be powerful 
 tools to illuminate the intermediate states that occur during these cellul
 ar transitions. I will discuss our work using single-cell transcriptomics 
 to reconstruct molecular paths during organ development and regeneration. 
 First\, I will present our work using single-cell transcriptomics to recon
 struct human organoid development and to compare these systems with their 
 primary counterparts. We are now manipulating these systems to study gene 
 function during human development and disease. Second\, I will discuss our
  work exploring regeneration of the axolotl forelimb\, where we found that
  connective tissue cell types in the uninjured adult limb revert to multip
 otent progenitor states that re-pattern and execute genetic programs obser
 ved in the embryonic limb.\n\nBio:\nBarbara Treutlein is Associate Profess
 or of Quantitative Developmental Biology at Department of Biosystems Scien
 ce and Engineering (D-BSSE)\, the Basel branch of ETH Zürich. Her researc
 h focuses on human developmental biology\, with a focus on how complex org
 ans such as the liver and brain form. Barbara was a Tenure Track Assistant
  Professor at the Technical University of Munich and Research Group Leader
  at the Max Planck Institute for Evolutionary Anthropology in Leipzig\, Ge
 rmany.\n\nZoom link for attending remotely: https://epfl.zoom.us/j/3580491
 53.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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