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SUMMARY:BioE COLLOQUIA SERIES:  Lipid Domains in Biological Membranes
DTSTART:20191118T121500
DTSTAMP:20260917T054017Z
UID:f676817f6d7671c29a94a473c2b199d558c1f8ab7a6e001ba3d01c24
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Liana C. Silva\, Research Institute for Medicines\, Facu
 lty of Pharmacy\, University of Lisbon (PT)\nWEEKLY BIOENGINEERING COLLOQU
 IA SERIES\n(sandwiches served)\n\nAbstract: \nThe biological roles of seve
 ral bioactive lipids have been linked to changes promoted by these molecul
 es on membrane structure and properties. Such alterations include the form
 ation of specialized membrane regions – lipid domains - that display spe
 cific lipid/protein composition\, and thus characteristic biophysical prop
 erties. Typical examples are the lipid rafts and the ceramide-platforms.\n
 \nIt is widely hypothesized that the compositional and biophysical distinc
 t features of lipid domains are the key for their specific biological role
 s. Therefore\, understanding how lipids modulate the biophysical propertie
 s of biological membranes will foster the knowledge of the molecular mecha
 nisms by which they regulate cellular events. However\, most of our presen
 t knowledge is limited to studies performed in artificial membranes or und
 er non-physiological mimicking conditions\, mainly due to the inherent com
 plexity associated to the study of lipid interactions in biological membra
 nes. To overcome this limitation\, we developed a bottom-up experimental s
 trategy that enables evaluating the biophysical impact of lipids in living
  cell membranes\, and evaluate their roles in physiological and pathologic
 al membrane dynamics.\n\nBio:\nLC Silva graduated in Biochemistry in 2001 
 at the Faculty of Sciences\, Universidade de Lisboa (UL)\, Portugal\, and 
 obtained her PhD degree in Chemistry (Molecular Biophysics) in 2006 at the
  Instituto Superior Técnico (IST-UL). She developed her post-doctoral pro
 ject at the interface between molecular biophysics and biochemistry as a r
 esearch fellow at the Weizmann Institute of Science (WIS)\, Israel and at 
 the IST (2007-2009). In 2009\, she was awarded a Ciência 2008 Research po
 sition to set her research team focused on Molecular & Cellular Biophysics
  at the Faculty of Pharmacy from the UL. She currently holds an Investigat
 or FCT research position at the same institution. LC Silva has an interdis
 ciplinary background in biochemistry and cell biology\, quantitative photo
 physics and molecular biophysics. Her research is multidisciplinary and br
 idges membrane biophysics and cell biology. She is interested in understan
 ding the role of membrane biophysical properties in cell function and path
 ology. Her research is focused on membrane lipids and their interplay in b
 iological membranes\, aiming at evaluating their role in membrane organiza
 tion and function\, and to provide the molecular tools to develop improved
  therapeutics.\n\nZoom link for attending remotely: https://epfl.zoom.us/j
 /300963982.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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