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SUMMARY:BioE COLLOQUIA SERIES:  Understanding and Controlling Protein Self
 -Assembly for Development of Therapeutic Materials
DTSTART:20191209T121500
DTSTAMP:20261001T230338Z
UID:f4bf9e3f772a20c0147488f149ace1a7ec53f345e0ff9e417984b8b6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Julie A. Champion\, Georgia Institute of Technology\, At
 lanta\, GA (USA)\nWEEKLY BIOENGINEERING COLLOQUIA SERIES\n(sandwiches serv
 ed)\n\nAbstract: \nProteins can provide therapeutic functions simply not p
 ossible with small molecule drugs\, but their large size and folded struct
 ure present critical challenges in terms of delivery\, stability and activ
 ity. We take advantage of protein size\, structure and the ability to inte
 ract with other proteins to create therapeutic protein materials via self-
 assembly routes not available for small molecules. The ability to control 
 assembly of therapeutic proteins is essential to manipulating the final ph
 ysical properties of the material\, ensuring retention of protein activity
 \, and directing the interactions between materials and cells. The main go
 al of our work is to create materials made directly from therapeutic prote
 ins and apply these to autoimmune disease\, vaccines and cancer. This is a
 ccomplished through a combination of self-assembly and/or bio-conjugation 
 processes. In each case\, we apply a rational protein design strategy and 
 perform extensive characterization to understand the structures formed\, t
 heir dynamics and stability\, and how to tune the material properties for 
 specific applications. These properties significantly affect how the prote
 in materials interact with biological systems and the current status of ap
 plication of these materials towards therapeutic targets will be shared.\n
 \nBio:\nResearch Interests:\n\n	Developing therapeutic protein materials\,
  where the protein is both the drug and the delivery system\n	Engineering 
 proteins to control and understand protein particle self-assembly\n	Repurp
 osing and engineering pathogenic proteins for human therapeutics\n	Creatin
 g materials that mimic cell-cell interactions to modulate immunological fu
 nctions for various applications\, including inflammation\, cancer\, autoi
 mmune disease\, and vaccination\n\n\nEducation:\n\n	B.S.E 2001\, Universit
 y of Michigan\n	Ph.D. 2007\, University of California\, Santa Barbara\n\n\
 n\nZoom link for attending remotely: https://epfl.zoom.us/j/942340541.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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