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SUMMARY:Defining Mitochondrial Protein Function Through Systems Biochemist
 ry
DTSTART:20191104T140000
DTEND:20191104T150000
DTSTAMP:20260407T014802Z
UID:75a2f57293eef0b53ef9ef88fcae17f7dd1860ead3b1d8ac80bc51ea
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David J. Pagliarini\, Morgridge Institute for Research a
 nd Department of Biochemistry\, University of Wisconsin–Madison\, Madiso
 n\, WI (USA)\nBIOENGINEERING SEMINAR\, co-organized with the LAUSANNE INTE
 GRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)\n\nAbstract:\nDespite th
 eir position as the iconic powerhouses of cellular biology\, many aspects 
 of mitochondria remain remarkably obscure—a fact that contributes to our
  poor ability to address mitochondrial dysfunction therapeutically. Such d
 ysfunction contributes to a vast array of human diseases through distinct 
 means. For instance\, aberrant mitochondrial biogenesis can fail to proper
 ly set cellular mitochondrial content\; dysregulated signaling processes c
 an fail to calibrate mitochondrial activity to changing cellular needs\; a
 nd malfunctioning proteins can render core bioenergetic processes ineffect
 ual. A major bottleneck to understanding—and ultimately addressing—the
 se processes is that the proteins driving them are often undefined. Concur
 rently\, the functions of hundreds of mitochondrial proteins that may fulf
 ill these roles are not known\, or at best are poorly understood. The high
 -level goal of my research program is to help achieve a more complete\, sy
 stems-level understanding of mitochondrial biology by systematically estab
 lishing the functions of orphan mitochondrial proteins and their roles wit
 hin disease-related processes. We do so by first devising multi-dimensiona
 l analyses designed to make new connections between these proteins and est
 ablished pathways and processes. We then employ mechanistic and structural
  approaches to define the functions of select proteins at biochemical dept
 h. This ‘systems biochemistry’ strategy is helping us address three ou
 tstanding biological questions: Which orphan mitochondrial proteins fulfil
 l the missing steps in classic mitochondrial processes\, including the bio
 synthesis of coenzyme Q and other aspects of respiratory chain function? W
 hat proteins assist in the orchestrated assembly of lipids\, metabolites\,
  and proteins (from two genomes) to ensure proper mitochondrial biogenesis
 ? And\, which resident signaling proteins direct the post-translational re
 gulation of mitochondrial activities? In answering these questions\, we ai
 m to help transform the mitochondrial proteome from a component list into 
 a metabolic circuitry of connected functions\, and to elucidate the bioche
 mical underpinnings of mitochondrial dysfunction in human disease.\n\nBio:
 \nDave Pagliarini is the Lead Investigator and Arthur C. Nielsen Jr. Chair
  of Metabolism at the Morgridge Institute for Research and an Associate Pr
 ofessor of Biochemistry at the University of Wisconsin-Madison. After grad
 uating with honors in from the University of Notre Dame\, Dave received a 
 Ph.D. in biochemistry under the direction of Jack Dixon at UC San Diego\
 , and performed his postdoctoral research with Vamsi Mootha at Harvard Me
 dical School/The Broad Institute.\n\nZoom link for attending remotely: htt
 ps://epfl.zoom.us/j/352381749\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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