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SUMMARY:The birth of cancers - a route to prevention
DTSTART:20200227T121500
DTEND:20200227T131500
DTSTAMP:20260916T065538Z
UID:674916437ac34e917de6cb59b916df1b2dd37ac9c5fc7fc57e58c739
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Richard J.Gilbertson  Li Ka Shing Chair of Oncology Head
  of Department of Oncology Director - Cambridge Cancer Center - CRUK Cambr
 idge Institute Li Ka Shing Centre - Cambridge\, UK  \n \nA Lola and John
  Grace Distinguished Lecture in Cancer Research\nThis seminar will also be
  televised to CHUV/AGORA\, Biopôle and Geneva University (rooms tbc)\n\n
  \nCancers are distributed unevenly in time and space: malignancies occur
  with predictable incidence in each organ system\, and despite enormous mi
 totic and differentiation stress\, cancers are rare in multi-organ species
  during development.  The relative importance of cell intrinsic and extri
 nsic factors in determining the topographical and temporal distribution of
  cancer risk is unknown. In published and ongoing work we have used Cre-re
 combination of conditional lineage tracing\, oncogene\, and tumour suppres
 sor alleles to define populations of stem and non-stem cells in mouse orga
 ns and test their life-long susceptibility to tumorigenesis. We show that 
 tumours arise solely within cells harbouring stem cell function\, and that
  neonatal stem cells are intrinsically resistant to cancer. This relations
 hip held true in the presence of multiple genotypes across all organs\, st
 rongly supporting the notion that stem cells dictate organ cancer risk. Us
 ing organ damage models\, we further show that damage-induced activation o
 f stem cell function markedly increases cancer risk. Finally\, in a large 
 ongoing mapping study we are charting the transcriptome\, proteome and met
 hylome of stem cell populations across twelve organs at multiple developme
 ntal time points from embryogenesis to old age. We propose that a combinat
 ion of stem cell mutagenesis and extrinsic factors that enhance the prolif
 eration of these cell populations\, creates a "perfect storm" that ultimat
 ely determines organ cancer risk. Furthermore\, understanding the mechanis
 m(s) by which neonatal stem cells resist cancer might unmask novel cancer 
 prevention strategies.\n \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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