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SUMMARY:Synthetic Human Embryo-Like Structure: A New Paradigm for Human Em
 bryology
DTSTART:20190830T100000
DTSTAMP:20260929T041143Z
UID:a9f42263364290bfaf70ebaa96b80046d6aa8a509c9d8b6e3c12b346
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jianping Fu\, University of Michigan\, Ann Arbor\, MI (U
 SA)\nBIOENGINEERING SEMINAR\n \nAbstract:\nEarly human embryonic developm
 ent remains mysterious due to drastic species divergences between humans a
 nd other mammalian models and limited accessibility to human embryo sample
 s.  Recent studies from my laboratory and others have shown that under su
 itable culture conditions human pluripotent stem cells (hPSCs) can undergo
  intricate morphogenetic events and self-organize to form patterned human 
 embryo-like structures in vitro.  These synthetic human embryonic-like ti
 ssues hold great promises for advancing human embryology and reproductive 
 medicine.  In this talk\, I will describe a hPSC-based\, synthetic 3D mod
 el of human post-implantation development that recapitulates key developme
 ntal landmarks successively\, including pro-amniotic cavity formation\, am
 niotic ectoderm-epiblast patterning\, primordial germ cell specification\,
  and development of the primitive streak with controlled anteroposterior p
 olarity.  We further show that the amniotic ectoderm\, as the first linea
 ge that segregates from the epiblast upon implantation of the human embryo
 \, functions as a signaling center to trigger primitive streak development
  in the epiblast.  Together\, our research has developed a powerful synth
 etic embryological model and provided new understandings of previously ina
 ccessible but critical embryogenic events in human development.\n\nBio:\nJ
 ianping Fu is currently an Associate Professor at the University of Michig
 an\, Ann Arbor\, with a primary appointment in the Mechanical Engineering 
 Department and courtesy appointments in the Biomedical Engineering Departm
 ent and the Cell and Developmental Biology Department.  He is a Core Facu
 lty Member for the UM Center for Organogenesis\, the UM Comprehensive Canc
 er Center\, and the UM Center for Systems Biology. Dr. Fu received a B.E
 . degree (2000) from the University of Science and Technology of China (U
 STC) and a M.S. degree (2002) from the University of California at Los An
 geles (UCLA)\, both in Mechanical Engineering.  He earned his Ph.D. degre
 e in Mechanical Engineering from the Massachusetts Institute of Technology
  (MIT) in 2007 for thesis completed with Dr. Jongyoon Han.  Dr. Fu was an
  American Heart Association Postdoctoral Fellow in Dr. Christopher S. Che
 n's group at the University of Pennsylvania from 2007 to 2009.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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