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SUMMARY:Quantitative Time-Resolved Dissection of Gene Expression and Cell 
 Identity
DTSTART:20191106T121500
DTEND:20191106T131500
DTSTAMP:20260502T060605Z
UID:cd235d1eab3c74913063ada1bef69f943d416d53cd945481e8d08224
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David Suter\, Institute of Bioengineering\, EPFL (CH)\nA
 bstract:\nThe genome contains the building plan of living organisms and la
 rgely determines their phenotype. Within complex multicellular animals\, t
 he differential activity of a common set of genes allows generating a larg
 e diversity of cell types. However\, the activity of individual genes dis
 plays large temporal fluctuations\, and mechanisms of gene regulation are 
 disrupted when cells enter into mitosis. How these perturbations impact t
 he control of cell identity is not understood.\nMy laboratory develops ne
 w approaches to dissect gene expression and cell fate decisions in a quan
 titative and time-resolved manner. I will first describe our quantificatio
 ns of transcription factor-DNA interactions\, the memory of gene activity 
 through cell generations\, and the coordination of protein synthesis and d
 egradation in single living cells. I will then discuss how temporal fluct
 uations of transcription factor levels and their activity across the cell
  cycle impact self-renewal and differentiation of embryonic stem cells. Ou
 r work illustrates how quantitative time-resolved analysis of gene express
 ion allows deepening our understanding of cell identity control.\n\nShort 
 bio:\nDavid Suter obtained his MD/PhD at the University of Geneva on stem 
 cell biology\, followed by a first postdoctoral training with Ueli Schible
 r focusing on single cell monitoring of transcription. He then joined the 
 group of Sunney Xie at Harvard University\, where he co-developed a new me
 thod for single molecule live imaging of transcription factors in mammalia
 n cells. In 2013\, he obtained a Swiss National Science Foundation Profess
 orship and was subsequently nominated Tenure Track assistant Professor at 
 the Institute of Bioengineering and EPFL School of Life Sciences. His rese
 arch focuses on quantitative approaches to study gene expression and devel
 opmental cell fate decisions.\n\nZoom link for attending remotely: https:/
 /epfl.zoom.us/j/143970197
LOCATION:SV 1717 https://plan.epfl.ch/?room=SV1717
STATUS:CONFIRMED
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