BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:IMX Seminar Series - Ultimately sensitive organic bioelectronic tr ansistor sensors DTSTART:20191216T131500 DTEND:20191216T141500 DTSTAMP:20260916T054429Z UID:c2268e39cce621dfc44239d58f00025e43b45540d6413d7e7f7bc9ff CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. Luisa Torsi\, University of Bari Italy\nOrganic bioelect ronic sensors are gaining momentum as they can combine high performance se nsing level with flexible large-area processable materials. This opens to potentially highly performing biomarkers sensing systems for point-of-care health monitoring at low-cost. Prominent to detect biochemical recognitio n events are the Electrolyte-Gated Organic Field-Effect Transistors that h ave been recently shown capable of label-free single-molecule detections\, even in blood serum.\nIndeed\, Label-free single-molecule detection has b een achieved so far by funneling a large number of analyte molecules into a sequence of single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense a c ue in a bulk milieu. Conceptualizing cells’ ability to sense at the phys ical limit by means of a transducing interface comprising highly-packed re cognition elements\, a millimetric sized electrolyte-gated field-effect-tr ansistor is used to detect a single molecule. To this end\, the gate is bi o-functionalized with a self-assembled-monolayer of trillions of capturing antibodies\, endowed with a hydrogen-bonding network enabling cooperative -interactions. The selective and label-free single-molecule detection is s trikingly demonstrated in diluted saliva while few tens of antigens are as sayed in whole serum. The suggested sensing mechanism triggered by the aff inity binding event\, involves a work-function change that is assumed to p ropagate in the gating-field through the electrostatic hydrogen-bonding ne twork. The proposed immunoassay platform is general and can revolutionize the current approach to protein detection.\nBio: Luisa Torsi received her PhD from the University of Bari and was post-doctoral fellow at Bell Labs and invited professor at the University of Anger and Paris 7. In 2005 she was appointed full professor of chemistry at the University of Bari and si nce 2017 she is adjunct professor at the Abo Academy University in Finland . In 2010 she was awarded with the Heinrich Emanuel Merck prize for analyt ical sciences\, this marking the first time the award is given to a woman. Recent main awards are also the International Union of Pure and Applied C hemistry 2019 Distinguished Women in Chemistry or Chemical Engineering pri ze and the analytical chemistry division of the European Chemical Society Robert Kellner Lecturer 2019. She has been also elected 2017 Fellow of the Material Research Society\, for pioneering work in the field of organic ( bio) electronic sensors and their use for point-of-care testing.\nIn 2014 she has been appointed as member of the H2020 Program Committee by the Ita lian Minister for Education and Research and is still serving in this role . She is also the immediate past president of the European Material Resear ch Society being the first women to serve on this role.\nAwarded research funding for over 26 million euros in thirteen years\, comprises several Eu ropean contracts as well as national and regional projects. She is present ly coordinating the SiMBiT project a H2020-ICT-2018-2020 research and inno vation action. Torsi is also coordinating a PRIN-17 national project (“A CTUAL” 2017RHX2E4).\nShe has authored almost 200 ISI papers\, including papers published in Science\, Nature Materials\, Nature Communications\, P NAS\, Advanced Materials\, Scientific Reports and is co-inventor of severa l international awarded patents. Her works gathered almost 11.100 Google s cholar citations resulting in an h-index of 50. She has given more than 17 0 invited lectures\, including almost 25 plenary and key notes contributio ns to international conferences.\n \n  LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201 STATUS:CONFIRMED END:VEVENT END:VCALENDAR