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SUMMARY:BMI SEMINAR // Brenda Bloodgood - The unexpected precision of an a
 ctivity-dependent transcription factor
DTSTART:20210519T170000
DTEND:20210519T180000
DTSTAMP:20260501T205742Z
UID:cbbfc071d7765f9a5a229be6975683a021c6d3c870f99f266bab9f1b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Brenda Bloodgood\, Division of Biological Sciences\, Departmen
 t of Neurobiology\nUniversity of California\, San Diego\, USA\nExceptional
 ly at 05:00 PM\n\nIn neurons\, activity-dependent transcription factors ar
 e expressed in response to a variety of stimuli and regulate gene expressi
 on that is associated with morphological\, synaptic and circuit plasticity
 . Because of this\, they are routinely used to identify behaviorally relev
 ant neurons in vivo. Yet\, it is unclear if a transcription factor conveys
  information to the nucleus about specific types of activity or how this i
 nformation is transformed into changes in connectivity. I will share recen
 t work from my lab describing how\, in the mouse hippocampus\, the transcr
 iption factor NPAS4 independently communicates changes in spiking and syna
 ptic activity to the nucleus. This information is then converted into prec
 ise changes in inhibitory circuit connectivity that reconfigures the compu
 tations performed by the neuron.\n 
LOCATION:https://epfl.zoom.us/j/96263948305
STATUS:CONFIRMED
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