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SUMMARY:BMI Seminar // Alain Chédotal - Development and evolution of neur
 onal connectivity
DTSTART:20220928T160000
DTEND:20220928T170000
DTSTAMP:20260510T131859Z
UID:8d08c032badfe53b6d2ed18e608d29efe7ac327e36fe7f817abee465
CATEGORIES:Conferences - Seminars
DESCRIPTION:Alain Chédotal\, Role of axon guidance molecules Lab\, Instit
 ut de la Vision\, Paris\, France\nIn most animal species including humans\
 , commissural axons connect neurons on the left and right side of the nerv
 ous system. In humans\, abnormal axon midline crossing during development 
 causes a whole range of neurological disorders ranging from congenital mir
 ror movements\, horizontal gaze palsy\, scoliosis or binocular vision defi
 cits. The mechanisms which guide axons across the CNS midline were thought
  to be evolutionary conserved but our recent results suggesting that they 
 differ across vertebrates.  I will discuss the evolution of visual projec
 tion laterality during vertebrate evolution.  In most vertebrates\, camer
 a-style eyes contain retinal ganglion cell (RGC) neurons projecting to vis
 ual centers on both sides of the brain. However\, in fish\, RGCs are thoug
 ht to only innervate the contralateral side. Using 3D imaging and tissue c
 learing we found that bilateral visual projections exist in non-teleost fi
 shes. We also found that the developmental program specifying visual syste
 m laterality differs between fishes and mammals. We are currently using va
 rious strategies to discover genes controlling the development of visual p
 rojections. I will also present ongoing work using 3D imaging techniques t
 o study the development of the visual system in human embryo.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/62550191552?pwd=OFRDVzBHb0cyVG1wYkxUSFFEMUNPdz09
STATUS:CONFIRMED
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