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SUMMARY:BMI SEMINAR // Gregory Scherrer - The neural basis of pain experie
 nce and its modulation by opioids
DTSTART:20211124T121500
DTEND:20211124T131500
DTSTAMP:20260427T200821Z
UID:012caaebf49316c5c158364859e33ecf2a38ac4c570d16538de4d9c4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gregory Scherrer\, University of North Carolina\, Chapel Hill\
 , USA\nIMPORTANT NOTICE // In-person attendance of this seminar is subject
 ed to some constraints:\n\n	Maximum number of participants is limited to 8
 0 \n	Valid COVID certificate and ID (e.g. Camipro card)\, required to ente
 r the conference room\, will be checked at the entrance\n	Face masks are m
 andatory for everyone in the seminar room (excepted the speaker while pres
 enting).\n\nHow the brain creates a painful experience remains a mystery. 
 Solving this mystery is crucial to understanding the fundamental biologica
 l processes that underlie the perception of body integrity\, and to creati
 ng better\, non-addictive pain treatments. My laboratory’s goal is to re
 solve the neural basis of pain. We aim to understand the mechanisms by whi
 ch our nervous system produces and assembles the sensory-discriminative\, 
 affective-motivational\, and cognitive-evaluative dimensions of pain to cr
 eate this unique and critically important experience. To capture every com
 ponent of the pain experience\, we examine the entirety of the pain circui
 try\, from sensory and spinal ascending pathways to cortical/subcortical c
 ircuits and brainstem descending pain modulation systems\, at the molecula
 r\, cellular\, circuit and whole-animal levels. For these studies\, we hav
 e invented novel behavioral paradigms to interrogate the affective and cog
 nitive dimensions of pain in mice while simultaneously imaging and manipul
 ating nociceptive circuits. My laboratory also investigates how opioids su
 ppress pain. Remarkably\, despite their medical and societal significance\
 , how opium poppy alkaloids such as morphine produce profound analgesia re
 mains largely unexplained. By identifying where and how opioids act in neu
 ral circuits\, we not only establish the mechanisms of action of one of th
 e oldest drugs known to humans\, but also reveal the critical elements of 
 the pain circuitry for developing of novel analgesics and bringing an end 
 to the opioid epidemic
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717 https://epfl.zoom.u
 s/j/96263948305
STATUS:CONFIRMED
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