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SUMMARY:Prof. Dr. Thomas Nevian: „Normal function and dendropathologies 
 of pyramidal neurons in the anterior cingulate cortex“
DTSTART:20190909T150000
DTEND:20190909T160000
DTSTAMP:20260506T195158Z
UID:fd437c5936f6e576e028be801e899ffe280ef8a84affeb76d7dccb4f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Thomas Nevian studied physics and biophysics in Heidelberg\, G
 ermany\, St. Andrews\, UK and at the Cornell University\, USA. He performe
 d his PhD work with Prof. Dr. Bert Sakmann at the Max-Planck-Institute for
  Medical Research in Heidelberg\, investigating the calcium dynamics in de
 ndrites of cortical neurons. After his dissertation in 2003 and two furthe
 r years as post-doc in Heidelberg\, he became a group leader in the Depart
 ment of Physiology at the University of Bern. In 2010 he received a Resear
 ch-Professorship of the Swiss National Science Foundation. In 2012 he was 
 appointed Tenure-Track-Assistentprofessor and since 2014 he is Full Profes
 sor of Physiology at the University of Bern. His groundbreaking research i
 n Neuroscience was awarded with the Pfizer Research Prize twice (2008\, 20
 16) and in 2012 he received the Theodor-Kocher-Preis as best young researc
 her of the University of Bern. In 2015 he received an ERC-Consolidator gra
 nt to study the neuronal networks involved in pain processing in the cereb
 ral cortex. He is associated to the Center for Cognition\, Learning and Me
 mory (CCLM)\, the Bern Network for Epilepsy\, Sleep and Consciousness (BEN
 ESCO) and he is a member of the steering comittee of the Clinical Neurosci
 ences Bern.\nAbstract: The anterior cingulate cortex (ACC) is an important
  brain area for pain perception. Particularly\, it is involved in the affe
 ctive/emotional processing of a painful experience. In chronic pain this b
 rain area becomes hyperactive. We are investigating the underlying mechani
 sms on the cellular and network level that result in the chronification of
  pain. Firstly\, the basic properties of dendritic function of layer 5 (L5
 ) pyramidal neurons\, the principal output cells of the ACC to subcortical
  brain regions\, will be presented. We found that the dendritic properties
  in the ACC differ from those of pyramidal neurons in the somatosensory co
 rtex. L5 pyramidal neuron dendrites possess particular low-pass filtering 
 properties that ensures very good propagation of slow signals of dendritic
  origin towards the soma. Secondly\, we investigated dendritic changes in 
 the condition of chronic pain and found a down regulation of the hyperpola
 rization and cyclic nucleotide dependent ion channel (HCN channel). This a
 ctivity-dependent „dendropathology“ resulted in increased summation of
  excitatory postsynaptic potentials (EPSPs). Finally\, invivo calcium imag
 ing of network function in the ACC revealed that the increase in cellular 
 excitability is reflected in increased network activity.\n 
LOCATION:B1 6 272.043 https://plan.epfl.ch/?room==B1%206%20272.043
STATUS:CONFIRMED
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