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BEGIN:VEVENT
SUMMARY:Cancer Genomes in 3D
DTSTART:20190925T121500
DTEND:20190925T131500
DTSTAMP:20260531T115316Z
UID:948064242bcdeaed00591676f9cf422a0d251c1057bf62105ca325dc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Robert Babak Faryabi\, University of Pennsylvania Perelman Sch
 ool of Medicine\, Philadelphia\, USA\nAbstract:  The importance of epigen
 etic changes in cancer pathogenesis has become increasingly clear\, yet th
 e underlying mechanisms remain obscure. Our research focuses on identifyin
 g epigenetic changes that can render cancer cells addicted to specific tra
 nscriptional regulators. I will present evidence that oncogenic subversion
  of transcription factors leads to disruption of chromosome topology and i
 nstruct enhancer elements to aberrantly contact and activate intact proto-
 oncogenes. These aberrant states can drive cancer cell growth and prolifer
 ation in the absence of genetic mutations\, and may also confer drug resis
 tance. I will also discuss our efforts to develop single-cell molecular to
 ols and experimental models for characterizing epigenetic mechanisms of on
 cogenesis and attendant therapeutic opportunities. 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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