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SUMMARY:Blue Brain Seminar - Normal function and dendropathologies of pyra
 midal neurons in the anterior cingulate cortex
DTSTART:20190909T150000
DTEND:20190909T160000
DTSTAMP:20260503T154113Z
UID:7e489983b5bbb38573501e8cfe145b7d08ab56d30904ca06689b63d7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Thomas Nevian\nBio: Thomas Nevian studied physics and biophys
 ics in Heidelberg\, Germany\, St. Andrews\, UK and at the Cornell Universi
 ty\, USA. He performed his PhD work with Prof. Dr. Bert Sakmann at the Max
 -Planck-Institute for Medical Research in Heidelberg\, investigating the c
 alcium dynamics in dendrites of cortical neurons. After his dissertation i
 n 2003 and two further years as post-doc in Heidelberg\, he became a group
  leader in the Department of Physiology at the University of Bern. In 2010
  he received a Research-Professorship of the Swiss National Science Founda
 tion. In 2012 he was appointed Tenure-Track-Assistentprofessor and since 2
 014 he is Full Professor of Physiology at the University of Bern. His grou
 ndbreaking research in Neuroscience was awarded with the Pfizer Research P
 rize twice (2008\, 2016) and in 2012 he received the Theodor-Kocher-Preis 
 as best young researcher of the University of Bern. In 2015 he received an
  ERC-Consolidator grant to study the neuronal networks involved in pain pr
 ocessing in the cerebral cortex. He is associated to the Center for Cognit
 ion\, Learning and Memory (CCLM)\, the Bern Network for Epilepsy\, Sleep a
 nd Consciousness (BENESCO) and he is a member of the steering comittee of 
 the Clinical Neurosciences Bern.\n\nAbstract: The anterior cingulate cort
 ex (ACC) is an important brain area for pain perception. Particularly\, it
  is involved in the affective/emotional processing of a painful experience
 . In chronic pain this brain area becomes hyperactive. We are investigatin
 g the underlying mechanisms on the cellular and network level that result 
 in the chronification of pain. Firstly\, the basic properties of dendritic
  function of layer 5 (L5) pyramidal neurons\, the principal output cells o
 f the ACC to subcortical brain regions\, will be presented. We found that 
 the dendritic properties in the ACC differ from those of pyramidal neurons
  in the somatosensory cortex. L5 pyramidal neuron dendrites possess partic
 ular low-pass filtering properties that ensures very good propagation of s
 low signals of dendritic origin towards the soma. Secondly\, we investigat
 ed dendritic changes in the condition of chronic pain and found a down reg
 ulation of the hyperpolarization and cyclic nucleotide dependent ion chann
 el (HCN channel). This activity-dependent „dendropathology“ resulted i
 n increased summation of excitatory postsynaptic potentials (EPSPs). Final
 ly\, invivo calcium imaging of network function in the ACC revealed that t
 he increase in cellular excitability is reflected in increased network act
 ivity.
LOCATION:B1 6 272.043 https://plan.epfl.ch/?room==B1%206%20272.043
STATUS:CONFIRMED
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