BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:Blue Brain Seminar - The organization and function of enigmatic ne ocortical layer 1 DTSTART:20191007T150000 DTEND:20191007T160000 DTSTAMP:20260407T212741Z UID:125868e0ff38011a7dae86e562e216332660907e7294d421a93d7e36 CATEGORIES:Conferences - Seminars DESCRIPTION:Bernardo Rudy\nBlue Brain is delighted to announce that the ne xt seminar in the series in Neural Computation\, will be on “The organiz ation and function of enigmatic neocortical layer 1’. The seminar will b e given by Prof. Bernardo Rudy from the Neuroscience Institute\, NYU Schoo l of Medicine where he is Professor\, Department of Anesthesiology\, Perio perative Care\, and Pain Medicine and Julius Raynes Professor of Neuroscie nce and Physiology\, Department of Neuroscience and Physiology.\n \nAbstr act:\nSensory perception depends on neocortical computations that contextu ally integrate signals from sensory organs (bottom-up or feed-forward inpu t) with internal information such as expectations\, predictions\, attentio n\, emotions and memories (top-down proessing). This results in the genera tion of a percept that is appropriate for the behavioral needs of the anim al. Bottom-up sensory information is first conveyed by the primary sensory thalamus to neocortical layers 4 and 5b/6 and is eventually relayed to th e basal dendrites of pyramidal cells (PCs)\, the output cells of the neoco rtex found in layers 2/3 and 5. On the other hand\, layer 1 (L1) is the ma in target of cortical and subcortical inputs that provide “top-down” i nformation for context dependent sensory processing. However\, the precise mechanisms that mediate contextual modulation remain unknown. L1 contains several poorly characterized subtypes of GABAergic interneurons. In addit ion\, L1 contains the dendrites of several types of interneurons with soma s in L2/3 and the axons of Martinotti cells\, a subtype of GABAergic inter neuron specialized for dendritic inhibition. L1 contains no excitatory cel ls\, but it contains the distal\, “tuft” dendrites of pyramidal cells in deeper layers. Understanding the processing of contextual signals by L1 interneurons and the interactions of these cells with the tuft dendrites of pyramidal cells\, is crucial to understand sensory perception. I will d escribe novel findings on the organization and structure of neocortical L1 in the mouse cortex that advance our knowledge of the mechanisms of conte xt dependent sensory perception.\n\nBio: Dr. Bernardo Rudy is a senior inv estigator interested in the organization and function of cortical circuits \, and the cellular and circuit mechanisms of information processing in th e neocortex. His lab has utilized molecular genetics and electrophysiologi cal recording in acute brain slices and in vivo to study brain circuits in volved in sensory processing\, the mechanisms of acetylcholine (ACh) modul ation of cortical circuits\, the diversity and function of cortical GABAer gic interneurons and the ion channels governing the functional properties of cortical neurons. Recently his lab developed a novel efficient and high -yield method (Channelrhodopsin-assisted patching) that allows the in vivo electrophysiological recording and labeling of neurons throughout the bra in. Together with the lab of Gordon Fishell the Rudy lab they have develop ed novel genetic strategies to unravel and study the diversity of GABAergi c interneurons in the neocortex and cholinergic neurons in the basal foreb rain. This application presents a comprehensive research program that util izes these and other innovations in addition to other cutting edge methods to achieve a new understanding of interneuron diversity in the neocortex and the mechanisms by which ACh regulates cortical activity and thereby he lp advance our knowledge of the mechanisms of sensory perception. His lab has a long-standing collaboration with the lab of Gordon Fishell\, and col laborates extensively with other members of the NYU Neuroscience Institute including Simon Peron\, Robert Froemke\, Michael Halassa\; Xiao-Jing Wang \; Michael Long\; Wenbiao Gan\, Dmitry Rinberg\, Alex Reyes\, Adam Carter\ , Tony Movshon\, Dan Sanes and Gyorgy Buzsaki. We also have a close collab oration with Dr. ZJ Huang at Cold Spring Harbor. Past trainees of the Rudy lab include 16 Ph.D. students and 19 postdoctoral fellows\, many of whom have become independent tenure-track faculty members or are doing research in industry (2). Dr. Rudy teaches in the Core Neuroscience Course of the Neuroscience Program at NYU and a course on Neural Circuits and Behavior w ith Robert Froemke. He is PI of our T32 training grant. Dr. Rudy assembled the team working on this U19 and will function as the PD of the U19 progr am\, as well as director of the administrative core and co-PI of Projects 1\, 2\, and 3.\n\nThe seminar is an open event\, at the Blue Brain offices in the Campus Biotech\, Geneva.  Upon arrival at the Campus Biotech\, pl ease sign in at the Campus Biotech reception.\n\nMonday 7 October 2019\n15 :00-16:00\n\nBlue Brain Project\nCampus Biotech\nChemin des Mines 9\nGenev a\n\nHost: Srikanth Ramaswamy\, Group Leader and Senior Scientist\, Blue B rain Project\n\nFor more information\, please contact info.bbp@epfl.ch\n\n How to get to the Seminar – https://www.epfl.ch/research/domains/bluebra in/blue-brain/contact/\n  LOCATION:B1 6 272.043 https://plan.epfl.ch/?room==B1%206%20272.043 STATUS:CONFIRMED END:VEVENT END:VCALENDAR