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SUMMARY:IMX Seminar Series - Bio-Synthetic Compartments as Mimics of Natur
 al Organelles
DTSTART:20191007T131500
DTEND:20191007T141500
DTSTAMP:20260928T233012Z
UID:cf54f4c8c984850a519ca77488aac492954f6db9783b8d7019ef50b0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Cornelia Palivan\, University of Basel Switzerland\nNew 
 concepts that combine active compounds with stable\, safe carriers or memb
 ranes resulting in functional systems are on focus in a variety of domains
 \, such as medicine\, catalysis\, environmental science\, food science and
  technology. In particular\, suitable amphiphilic block copolymers are ide
 al candidates for generation of 3D supramolecular assemblies\, such as com
 partments\, micelles\, nanotubes or planar membranes. Such synthetic flexi
 ble membranes have a superior stability\, and robustness compared to the l
 ipid based membranes\, and can be obtained with a variety of physical and 
 chemical properties. By combining such polymeric assemblies with suitable 
 biological entities\, e.g.\, by enzyme encapsulation in polymer compartmen
 ts or biomolecules attachment at their surface\, it is possible to provide
  well-defined functions\, such as molecular recognition\, cooperation\, an
 d catalytic activity.1\nHere\, we present distinct spaces for desired reac
 tions at the nano- and micrometer scale based on protein-polymer assemblie
 s that play the role of artificial organelles when internalized in cells2 
 or of simple protocells.3 Biopores/channel proteins inserted into the poly
 mer membrane selectively control the exchange of substrates and products\,
  resulting in development of stimuli-responsive compartments\, which prese
 rve their architecture\, while allowing specific in situ reactions. This g
 eneral strategy based on combination of synthetic assemblies and biomolecu
 les supports the development of artificial organelles\, proved to be funct
 ional in vitro and in vivo\, in Zebra fish2 or of compartments mimicking c
 ellular processes inside.3\n1.  A. Belluati\, I. Craciun\, J. Liu\, C.G. 
 Palivan\, Biomacromolecules\, 19: 4023–4033\, 2018.\n2.  T. Einfalt\, D
 . Witzigmann\, C. Edlinger\, S. Sieber\, R. Goers\, A. Najer\, M. Spulber\
 , O. Onaca-Fischer\, J. Huwyler\, C. G. Palivan\, Nature Comm.\, 9: 1127-1
 134\, 2018.\n3. S. Thamboo\, A. Najer\, A. Belluati\, C. von Planta\, D. W
 u\, I. Craciun\, W. Meier\, C. G. Palivan\, Adv. Funct. Mater.\, 1904267: 
 1-12\, 2019.\n\nBio: Cornelia G. Palivan received her Ph.D. degree in Phys
 ics at the University of Bucharest\, after a two years research stage at t
 he University of Geneva. Currently Professor in Physical Chemistry of the 
 University of Basel and member of the Swiss Nanoscience Institute\, she ha
 s as main scientific interests the development of functional bio-artificia
 l systems that interface biomolecules (enzymes\, proteins\, DNA\, mimics a
 nd combinations of thereof) with supramolecular synthetic assemblies (nano
 particles\, polymersomes\, solid-supported planar membranes\, etc). Such h
 ybrid bio-artificial systems provide optimum conditions for complex reacti
 ons at the nanoscale\, and thus support translational applications in doma
 ins such medicine\, catalysis\, food- or environmental-sciences. She recei
 ved during her career several prizes\, awards and fellowships.\n 
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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