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SUMMARY:Polymeric modules for synthetic biology
DTSTART:20191105T111500
DTSTAMP:20260503T073615Z
UID:69bebba0b48b576dfbad704afc3799e8e64dccc01f20c5eb4fe18c86
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Katharina Landfester \nSince many years\, there is a 
 quest for minimal cells in the field of synthetic biology\, potentially al
 lowing a maximum of efficien­cy in biotechnological processes. Although t
 he so-called “protocells” are usually referred to in all papers that a
 ttempt a cumulative definition of Synthetic Biology\, research in this are
 a has been largely under-represented. The aim of the Landfester lab is to
  develop vesicular structures\, i.e. protocells\, based on block copolymer
  self-assembly and engulfed nanocontainers with incorporated functions\, s
 uch as energy production and the control of transport properties through n
 anomembranes. They have designed and developed nanocapsules that act as ce
 ll-like compartments and can be loaded with enzymes for synthetic biology 
 and chemistry. In addition\, self-assembly of well-defined diblock copolym
 ers has been used to generate polymersomes and hybrid liposomes/polymersom
 es. Both strategies allow the compartimentalization on the nano- or micros
 cale and conducting enzymatic or chemical reactions in the confinement of 
 the polymersomes/ nanocarriers. New block copolymers and permeable nanocar
 riers have been synthesized and optimized. With these protocols\, the Land
 fester lab established an enzymatic reaction cascade within droplet-based 
 compartments. These compartments can act as cell-like functions to regener
 ate NAD. For these tasks\, novel conductive polymer nanoparticles have bee
 n developed which will be included into the protocells for the NAD regener
 ation by light. Also enzyme-complexes are assembled that will fulfill thes
 e requirements.\n\nKatharina Landfester received her doctoral degree in P
 hysical Chemistry after working in 1995 at the Max Planck Institute for P
 olymer Research (MPIP). After a postdoctoral stay at the Lehigh Universit
 y (Bethlehem\, PA)\, she worked at the Max Planck Institute of Colloids an
 d Interfaces in Potsdam (Germany) leading the mini-emulsion group. From 20
 03 to 2008\, she was full professor at the University of Ulm. At the MPIP\
 , she started her activities in the field of biomedical applications in co
 operation with several medical groups working on the interaction of nanopa
 rticles with different cell compartments\, the labelling of cells and the 
 delivery of substances to specific sides. She joined the Max Planck Societ
 y in 2008 as one of the directors of the MPIP. She was awarded the Reimu
 nd Stadler prize of the German Chemical Society and the prize of the Dr. H
 ermann Schnell Foundation\, followed by the Bruno Werdelmann Lecturer in 2
 012 and the Bayer Lecturer in 2014. Her research focusses on creating func
 tional colloids for new material and biomaterial applications. She has pub
 lished more than 650 papers in international journals\, 30 reviews and hol
 ds more than 50 patents.\n 
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