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SUMMARY:Transcription Factors As Sensors and Modifiers of Chromatin
DTSTART:20191016T110000
DTEND:20191016T120000
DTSTAMP:20260506T195242Z
UID:16efca749279f3fdd0ca741819b4e823ba5153cb1f0e8b43d94ba85a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dirk Schübeler\, Friedrich Miescher Institute for Biom
 edical Research\, Basel (CH)\nBIOENGINEERING SEMINAR\n \nAbstract:\nTrans
 cription factors only bind a minority of their motifs in large mammalian g
 enomes. One potential explanation is that many motifs are not accessible f
 or binding due to the action of chromatin and DNA methylation. We are usin
 g mammalian stem cell models to understand this important interplay betwee
 n gene regulation\, chromatin structure and DNA methylation. We study the 
 dynamics of the epigenome and test regulatory models in cellular models by
  genetic perturbation and genome editing approaches.\n \nIn my talk I wil
 l discuss our recent efforts in understanding how the sensitivity to DNA m
 ethylation can limit transcription factor binding in the context of the ce
 ll and how TFs rely on specific chromatin remodelers for access to their b
 inding sites. \n\nBio:\nEducation:\n1998     PhD\, Technical Universit
 y\, Braunschweig (D)\n1995     MSc\, Technical University\, Braunschwei
 g (D)\n\nPositions held:\n2019-            Co-Director FMI\n2008-
             Senior Group Leader\, Friedrich Miescher Institute fo
 r Biomedical Research\, Basel (CH)\n2003-2007     Junior Group Leader\,
  Friedrich Miescher Institute for Biomedical Research\, Basel (CH)\n1998-2
 003     Postdoctoral Fellow\, Fred Hutchinson Cancer Research Center\, 
 Seattle\, WA (USA)
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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