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SUMMARY:Epigenetic Mechanisms and Intratumour Functional Heterogeneity
DTSTART:20200430T121500
DTEND:20200430T133000
DTSTAMP:20260528T175151Z
UID:a75b5dc189d26ac40515ffbd269aef032eceecf0a7c00d994c2ce4b6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Paola SCAFFIDI Cancer Epigenetics Laboratory The Francis
  Crick Institute London - UK\nA Lola and John Grace Distinguished Lecture 
 in Cancer Research\nThis seminar will also be televised to CHUV Visioconf
 érence 2 + Biopôle B301/CLE + Geneva University-CMU Auditorium Paul Boym
 ond B02.226\n \nPaola Scaffidi obtained her PhD from the Open University 
 of London\, working at San Raffaele Institute in Milan\, Italy. Her PhD wo
 rk in Marco Bianchi’s group led to the identification of the chromatin p
 rotein HMGB1 as a major danger signal released by damaged cells\, which tr
 iggers inflammatory responses. She then moved to the US National Cancer In
 stitute to work in Tom Misteli's laboratory. Her postdoctoral studies focu
 sed on the premature ageing disease Hutchinson-Gilford Progeria Syndrome a
 nd aimed at elucidating how nuclear architecture affects genome function a
 nd how it contributes to the ageing process. As a staff scientist\, she in
 itiated a new area of investigation focused on understanding how cellular 
 reprogramming affects the initiation and maintenance of solid tumours. In 
 2014\, she established her own lab at the CRUK London Research Institute\,
  which then became part of the Francis Crick Institute.  The Cancer Epige
 netics lab investigates epigenetic mechanisms important for cancer develop
 ment\, with a particular focus on chromatin-based processes.\n\nThe common
  theme that links the various stages of my career is the study of how dere
 gulation of gene expression leads to disease. I have obtained my PhD from 
 the Open University of London\, working at San Raffaele Institute in Milan
 \, Italy. My PhD work led to the identification of the chromatin protein H
 MGB1 as a major danger signal released by damaged cells that alerts the im
 mune system and triggers sterile inflammation. I then moved to the US Nati
 onal Cancer Institute to work in Tom Misteli's laboratory. My postdoctoral
  studies focused on the premature ageing disease Hutchinson-Gilford Proger
 ia Syndrome and investigated how nuclear architecture affects genome funct
 ion and how it contributes to the ageing process. As a staff scientist\, I
  initiated a new area of investigation focused on understanding how cellul
 ar reprogramming affects the initiation and maintenance of solid tumors. I
 n 2014\, I established the Cancer Epigenetics Laboratory at the CRUK Londo
 n Research Institute\, which then became part of the Francis Crick Institu
 te. A major goal of the laboratory is to uncover the functional impact of 
 epigenetic and transcriptional deregulation in cancer. To do so\, we study
  how chromatin-based mechanisms cooperate with genetics and cell-to-cell s
 ignaling in defining cancer cell behavior at various stages of the disease
 .\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CANCELLED
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