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SUMMARY:Studying ubiquitin-like proteins across the domains of life
DTSTART:20191203T161500
DTEND:20191203T173000
DTSTAMP:20260930T033659Z
UID:4df6d46b89d92a528fab0f1af124da87f89aaec683e5c455a617fd04
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Champak Chatterjee\, University of Washington\, Seattle\
 nThe prokaryotic ubiquitin-like protein (Pup) is found in the disease-ca
 using bacterium Mycobacterium tuberculosis that infects about a third of
  the world’s population. Protein modification by Pup\, called pupylation
 \, is necessary for the persistence of tuberculosis infection. Hence\, the
  enzymes associated with pupylation are potentially new targets in drug-re
 sistant tuberculosis. Chatterjee lab has developed new chemical probes for
  mechanistic studies of the enzymes associated with protein pupylation. Ke
 y insights gained from biochemical studies with these probes\, which led t
 o the development of peptide inhibitors of protein pupylation will be pres
 ented.\nIn contrast with Pup\, the small ubiquitin-like modifier protein\
 , SUMO\, is a human protein critical for gene regulation and repair. Lysi
 ne side-chain modification by SUMO is a conserved modification of many imp
 ortant nuclear proteins\, such as transcription factors and histones. Chat
 terjee lab has developed facile chemical strategies to synthesize human pr
 oteins modified by SUMO. Champak Chatterjee will present results from biop
 hysical and biochemical studies enabled by his synthesis\, and propose a m
 odel for gene regulation by histone sumoylation.\n \nAbout Champak Chatte
 rjee\nChampak received his B.Sc. in Chemistry (First Class) from the Unive
 rsity of Bombay\, and an M.Sc. in Organic Chemistry from I.I.T. Bombay (In
 stitute Silver Medal)\, where he synthesized non-natural amino acids in th
 e laboratory of Prof. Sambasivarao Kotha. Champak then moved to the U.S. a
 nd performed doctoral studies in the research group of Prof. Wilfred van d
 er Donk at the University of Illinois at Urbana-Champaign. At Illinois\, C
 hampak studied the mechanism of biosynthesis of a class of ribosomally syn
 thesized and post-translationally modified peptide antibiotics called lant
 ibiotics or RiPPs. His post-doctoral work in Prof. Tom Muir’s laboratory
  at the Rockefeller University focused on understanding the mechanism by w
 hich ubiquitin stimulates histone methylation\, and developing new methods
  for the site-specific modification of proteins.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
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