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SUMMARY:PhD defense open seminar:  In vivo diffusion magnetic resonance im
 aging of the white matter microstructure from dictionaries generated by Mo
 nte Carlo simulations: development and validation
DTSTART:20191022T153000
DTEND:20191022T163000
DTSTAMP:20260527T230113Z
UID:0b2dc98dc39666c5681a06b64ea3b03efaaf10be0dd4f7446c1e51b2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gaetan Rensonnet\nAbstract:\nMany neurological and psychiatri
 c disorders are closely related to subtle alterations of white matter cel
 ls such as axons\, i.e.\, the long cables interconnecting the different a
 reas of gray matter. The ability to predict microstructural properties of
  those cells in vivo using a non-radiating technique would therefore hav
 e far-reaching consequences in neuroscience and in clinical practice. \nI
 n this thesis\, a framework was developed for the estimation of the whit
 e matter microstructure based on diffusion-weighted magnetic resonance im
 aging (DW-MRI)\, a non-invasive imaging modality sensitive to the microme
 ter-scale displacements of water molecules undergoing diffusion the brain.
  The proposed approach\, dubbed microstructure fingerprinting\, relied on 
 numerical Monte Carlo simulations of water diffusion rather than on clo
 sed-form mathematical formulas. On a variety of small animal and healthy
  human subject experiments\, it was shown to be more robust and interpret
 able than traditional models. The flexibility of the proposed method sho
 uld allow various refinements to be incorporated in the future\, ultimatel
 y advancing our understanding of the white matter and improving the manage
 ment of brain disorders. 
LOCATION:ELD 020 https://plan.epfl.ch/?room==ELD%20020
STATUS:CONFIRMED
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