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SUMMARY:Kinetic asymmetry allows macromolecular catalysts to drive an info
 rmation ratchet
DTSTART:20191029T140000
DTSTAMP:20260916T082113Z
UID:f461deb73d84f25947d759d6ca09f9bfc14aea441d1b6be12b65162f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. R. Dean Astumian\, Professor\, Department of Physics\, T
 he University of Maine\nMolecular machines carry out their function by equ
 ilibrium mechanical motions in environments that are far from thermodynami
 c equilibrium. The mechanically equilibrated character of the trajectories
  of the macromolecule has allowed development of a powerful theoretical de
 scription\, reminiscent of Onsager’s trajectory thermodynamics\, that is
  based on the principle of microscopic reversibility. Unlike the situation
  at thermodynamic equilibrium\, kinetic parameters play a dominant role in
  determining steady-state concentrations away from thermodynamic equilibri
 um\, and kinetic asymmetry provides a mechanism by which chemical free-ene
 rgy released by catalysis can drive directed motion\, molecular adaptation
 \, and self-assembly. Several examples drawn from the recent literature\, 
 including a catenanebased chemically driven molecular rotor and a syntheti
 c molecular assembler or pump\, will be discussed.
LOCATION:BSP 727 https://plan.epfl.ch/?room==BSP%20727
STATUS:CONFIRMED
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