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BEGIN:VEVENT
SUMMARY:How To Build a Biological Nanomachine
DTSTART:20191025T093000
DTEND:20191025T103000
DTSTAMP:20260926T151707Z
UID:7d07e1778d582633daa91e0cdf69ac017fae8b58c646d2e1c2403fd1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Anđela Šarić\, University College London (UK)\nBIOENG
 INEERING SEMINAR\n \nAbstract:\nThe molecular machinery of life is large
 ly created via self-organisation of individual molecules into functional 
 assemblies. Such processes are multi-scale in nature and constantly drive
 n far from thermodynamic equilibrium. Our group develops minimal computer 
 models to help understand how a large number of macromolecules self-organi
 ses into a functional nanomachine.\nHere I will discuss the physical mecha
 nisms behind two key biological nanomachines that operate via protein asse
 mbly – ESCRTIII filaments that remodel cell membranes and split evolutio
 nary simple cells in two\, and bacterial mechanosensitive channels that co
 nvert mechanical signals into chemical. I will discuss the model developme
 nt\, the simulation results\, and the mapping of the simulation data to in
  vivo experiments. Beyond their biological context\, our findings can also
  guide the design of artificial structures that are able to perform work a
 t the nanoscale.\n\nBio:\nAnđela Šarić is an Associate Professor of Bi
 ological and Soft Matter Physics at University College London (UK). She ob
 tained a PhD from Columbia University in New York\, followed by a postdoc 
 at the University of Cambridge (UK). Her research is currently focused on 
 functional and pathological protein assembly and cell remodeling. She is a
  recipient of the Royal Society University Resea​rch Fellowship and the
  ERC Starting Grant.\n\n\nZoom link for attending remotely: https://epfl.z
 oom.us/j/844875598
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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