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SUMMARY:DENR-Mediated Translation Reinitiation and Links to the Circadian 
 Clock
DTSTART:20191121T100000
DTEND:20191121T110000
DTSTAMP:20260922T031324Z
UID:8742bbf2255df70e4d9790baedf2503a0bac5e052f0e98ccd6112dc4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Violeta Castelo Szekely\, CIG\, University of Lausanne\, C
 H (until April 2019)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and N
 UTRITION ALLIANCE (LIMNA)\n\nAbstract:\nThe non-canonical initiation facto
 r DENR promotes translation reinitiation on mRNAs harbouring upstream open
  reading frames (uORFs). Moreover\, DENR depletion shortens circadian peri
 od in mouse fibroblasts\, suggesting involvement of uORF usage in clock re
 initiation. In this study\, ribosome profiling was used to identify DENR-r
 egulated transcripts transcriptome-wide and within the clock circuitry. 24
 0 transcripts were uncovered with altered translation rates\, and linear r
 egression was used to extract predictive features of DENR dependance. Amon
 g core clock genes\, Clock was identified as a DENR target\, whose protein
  biosynthesis is regulated through two uORFs and an alternative coding seq
 uence start codon. These findings provide insights into uORF-mediated tran
 slational regulation that control the mammalian circadian clock and gene e
 xpression at large.\n 
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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