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SUMMARY:BMI SEMINAR  // Ana Maria Cuervo - Targeting selective autophagy a
 gainst neurodegenerative diseases
DTSTART:20210421T121500
DTEND:20210421T131500
DTSTAMP:20260919T212641Z
UID:178faa9f934013f89972030a4d5fbb8c0c3da4d28a0d3cec6373c56e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ana Maria Cuervo\, Albert Einstein College of Medicine\, New Y
 ork\, USA\nProtein quality control is essential for maintenance of a healt
 hy and functional proteome that can attend the multiplicity of cellular fu
 nctions. Failure of the systems that contribute to protein homeostasis\, t
 he so called proteostasis networks\, have been identified in the pathogene
 sis of multiple neurodegenerative disorders and demonstrated to contribute
  to disease onset and progression.  We are interested in autophagy\, one 
 of the components of the proteostasis network\, and in the interplay of wo
  selective types of autophagy\, chaperone-mediated autophagy (CMA) and end
 osomal microautophagy (eMI)\, with neurodegeneration.\nWe have recently fo
 und that pathogenic proteins involved in common neurodegenerative conditio
 ns such as tauopathies or Parkinson’s disease\, can exert a toxic effect
  in both types of selective types of autophagy compromising their function
 ing. We have now used mouse models with compromised CMA that support incre
 ased propagation of proteins such as tau and alpha-synuclein and an exacer
 bation of disease phenotype with aging. Conversely\, genetic or chemical u
 pregulation of CMA in this context of proteotoxicity slow down disease pro
 gression by facilitating effective intracellular removal of pathogenic pro
 teins. Our findings highlight CMA and eMI as potential novel therapeutic t
 argets against neurodegeneration.\n 
LOCATION:https://epfl.zoom.us/j/96263948305
STATUS:CONFIRMED
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