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SUMMARY:Memory aids on the chromatin ? Deciphering epigenetic mechanisms o
 f memory storage and change
DTSTART:20200121T121500
DTEND:20200121T131500
DTSTAMP:20260408T050428Z
UID:1c656d7267cf8698f2d11f026d1bdae0e6237999b84f1cafed29854a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Johannes Graeff\, SV / BMI / UPGRAEFF\nAbstract :\nMy labo
 ratory is interested in the cellular and molecular underpinnings of memory
 . To investigate these\, we focus on neuroepigenetic processes and hypothe
 size that with their Janus-faced property of being at once dynamic and sta
 ble\, epigenetic mechanisms harbor the potential to better explain memory 
 formation\, storage and loss. Of special interest in the lab are memory de
 terioration in Alzheimer’s disease (AD)\, and particularly robust memori
 es such as those occurring in post-traumatic stress disorder (PTSD). For t
 he former\, we have thus far revealed the first methylation quantitative t
 rait locus (mQTL) in AD\, and thereby identified a novel candidate gene 
 – PM20D1 – that bestows neuroprotection. For the latter\, we have deli
 neated key brain areas and cellular subpopulations implicated in the atten
 uation of long-lasting traumatic memories\, and thereby provided the first
  engram-specific evidence for memory updating that may underlie the treatm
 ent of PTSD. These achievements now enable the next level of investigation
  of PM20D1-related and engram-specific epigenetics essential for memory st
 orage and change.\n\nShort Bio :\nJohannes Gräff is Assistant Professor o
 n Tenure Track at the Brain Mind Institute of the School of Life Sciences 
 at EPFL\, Switzerland. Originally from St. Gallen\, Switzerland\, he obtai
 ned his M.Sc. from the University of Lausanne\, his PhD under the guidance
  of Isabelle Mansuy at ETHZ\, and conducted his postdoctoral studies in th
 e laboratory of Li-Huei Tsai at the Picower Institute of Learning and Memo
 ry at MIT. In 2014\, he has received the Young Investigator Award of the S
 wiss Society for Biological Psychiatry\, and in 2020 the Boehringer Ingelh
 eim FENS Research Award.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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