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VERSION:2.0
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SUMMARY:CIBM Research Seminar - Measuring metabolite diffusion with diffus
 ion-weighted MR spectroscopy
DTSTART:20191213T131500
DTEND:20191213T151500
DTSTAMP:20260406T111849Z
UID:de29b95b4c80efa60dd013815202fa3e005c020bee900d44c109f8fb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Julien Valette\, Commissariat à l’Energie Atomique (CEA
 )\, Paris\nAbstract: Diffusion-weighted NMR spectroscopy (DW-MRS) offers t
 he unique ability to non-invasively quantify the diffusion of endogenous m
 etabolites in vivo. In contrast to water\, which is ubiquitous in biologi
 cal tissues\, most metabolites are confined within cells. Their diffusion 
 properties are thus expected to mostly depend on intracellular parameters 
 such as cytosol viscosity\, molecular crowding\, size and shape of the cel
 l… Furthermore\, in the brain\, some metabolites are thought to exhibit 
 preferential compartmentation\, with N-acetyl-aspartate (NAA) and glutam
 ate (Glu) being mostly in neurons\, while myo-inositol (mIns) and chol
 ine compounds (tCho) are thought to be preferentially compartmentalized i
 n glial cells. Cellular specificity has been the main motivation driving 
 methodological research and applications of DW-MRS in vivo over the last
  25 years.\nWe will first evoke some general difficulties and advantages o
 f metabolite diffusion as compared to water diffusion. Then\, we will brow
 se the main applications of DW-MRS to date\, including the determination o
 f lipid droplets diameter\, the measurement of alterations of metabolite a
 pparent diffusion coefficient (ADC) in brain diseases\, and more recently 
 the modeling of DW-MRS data to gain some quantitative information about br
 ain cell microstructure. Finally\, in a more technically-oriented section\
 , we will examine how to implement DW-MRS.\n\nBiography: Dr. Julien Vale
 tte worked as a scientific project leader at NeuroSpin (CEA)\, where he de
 veloped a new approach for high-sensitivity MRI of 19F\, allowing the det
 ection of targeted contrast agents in a mouse model of glioblastoma. Since
  2009\, he is the manager of the NMR platform and the leader of the NMR te
 am in MIRCen\, a preclinical facility of CEA aiming at developing new anim
 al models\, therapeutic strategies and imaging tools for neurodegenerative
  diseases. The main focus of his current research is the development and a
 pplication of diffusion-weighted NMR spectroscopy methods in vivo to qua
 ntify brain cells structure and metabolic compartmentation\, for which he 
 got a Starting Grant from the European Research Council in 2013 and a Cons
 olidator Grant in 2018.
LOCATION:CH F1 614 https://plan.epfl.ch/?room==CH%20F1%20614
STATUS:CONFIRMED
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