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SUMMARY:BMI Progress Reports 2020 // Prof. Sanid's Lab: Elias Gebara - Mit
 ofusin-2 in the nucleus accumbens links high anxiety with mitochondrial an
 d neuronal structure and function and behavior
DTSTART:20200212T121500
DTEND:20200212T130000
DTSTAMP:20260916T060029Z
UID:e5f01027b50efd74741931b010bf871c803bb5d3c22509359caa078f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Elias Gebara\nMitochondrial dysfunction is increasingly implic
 ated in brain function and psychopathologies. Mitofusin 2 (Mfn2) is molecu
 le involved in mitochondrial dynamics and is essential for the regulation 
 of energy production under stress conditions and for mitigating mitochondr
 ial resulting from environmental challenges. In this study\, we investigat
 e the involvement of Mfn2 in a brain region\, the nucleus accumbens that p
 lays a key role in motivation and is implicated in depression\, in the vul
 nerability to develop anxiety and depression following stress exposure. Wi
 star outbred rats were first classified as high- or low-anxious based on n
 atural variation for anxiety-like behavior on the elevated plus maze. High
 -Anxious rat displayed a decrease in Mfn2 RNA and protein levels\, coupled
  with a change mitochondria morphology and function. These changes results
  in an alteration in neuronal morphology and physiology affecting the beha
 vior. We injected a Mfn2 overexpressing AAV in the nucleus accumbens of hi
 gh-Anxious rat and we found that after 4 weeks of incubation we restore th
 e neuronal morphology and the behavior. Our results suggests that mfn2 pla
 ys a major role in the neuronal function and the anxiety related behavior.
 \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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