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PRODID:-//Memento EPFL//
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SUMMARY:WEBINAR - BMI Progress Reports 2020 // Prof. Gräff's Lab: Giulia 
 Santoni - An epigenetic contribution to neuronal competition during memory
  formation
DTSTART:20200513T121500
DTEND:20200513T130000
DTSTAMP:20260407T064349Z
UID:53700ce10eee638f5093c76f4281a8a3826a41f35f530bbba3de397b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Giulia Santoni\nOver the past years\, multiple lines of eviden
 ce have suggested that long-lasting memories are stored in a small set of 
 neurons scattered throughout the brain\, so-called engram cells (Josselyn 
 et al.\, 2015\, Nat Rev Neurosci\; Tonegawa et al.\, 2015\, Neuron). From 
 these studies it is becoming apparent that during the process of memory fo
 rmation\, each region of the brain involved in memory storage recruits bet
 ween 5 and 20 percent of excitatory neurons to define a stable engram. Hen
 ce\, as memories start to be encoded\, the size constraint of the engram t
 o be formed likely imposes neurons to enter in competition for memory allo
 cation. Indeed\, recent studies have revealed that the neuronal competitio
 n to participate in the memory engram is not random\; rather\, post-synapt
 ic neurons with a higher excitability then their neighbors are more likely
  to be selected into the memory trace (Zhou et al.\, 2009\, Nat Neurosci\;
  Yiu et al.\, 2014\, Neuron).\nThis project wants to further explore the p
 rocess of memory allocation by studying how epigenetic mechanisms contribu
 te to neuronal selection. Specifically\, we will focus on one of the main 
 epigenetic modifications studied in learning and memory: histone acetylati
 on (Gräff and Tsai\, 2013\, Nat Rev Neurosci). Our hypothesis is that bas
 ed on its epigenetic make-up\, and depending on the transcriptional outcom
 e of such epigenetic code\, a neuron will acquire certain transcriptomic s
 ignatures that define its engagement in memory formation.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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