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SUMMARY:WEBINAR - BMI Progress Reports 2020 // Prof. Markam's Lab - Jane Y
 i: Thalamic microcircuitry: neurons\, synapses\, and circuit motifs in rec
 eptive field structure and sensory processing
DTSTART:20200916T121500
DTEND:20200916T130000
DTSTAMP:20260407T042143Z
UID:60154b67ccc72adc996ec38bdb1edb5956ca1ebf5e6c8a57a7b200ea
CATEGORIES:Conferences - Seminars
DESCRIPTION:Thalamic interneurons play a crucial role in enhancing percept
 ion by sharpening spatial and temporal features of incoming stimuli (Hirsc
 h et al.\, 2015\; Martinez et al.\, 2014\; Wang et al.\, 2011). Despite th
 eir presence in other thalamic nuclei\, thalamic interneurons are almost e
 xclusively studied in the visual thalamic nucleus\, the lateral geniculate
  nucleus (LGN)\, due to their greater numbers (Arcelli et al.\, 1997\; Eva
 ngelio et al.\, 2018). The somatosensory thalamic nuclei of the rodent bra
 in\, collectively known as the ventrobasal (VB) nucleus\, contain a local 
 interneuron population percentage of less than 1% (Arcelli et al.\,1997)\,
  though conflicting reports have been reported up to 4.2% (Cavdar et al.\,
  2014). On the other hand\, interneurons in the LGN represent between 5.6 
 and 20% of the neuronal population (Arcelli et al.\, 1997\; Evangelio et a
 l.\, 2018). Given the sparse population of these cell types in the VB\, th
 eir properties and contributions to thalamic functions have been vastly ov
 erlooked. However\, the morphologies of their LGN counterparts display den
 se dendritic arborization patterns that span hundreds of micrometers (Morg
 an et al.\, 2020\; Zhu and Lo\, 1999)\, suggesting a profound influence on
  thalamocortical relay (TC) excitatory tone throughout the nucleus. In thi
 s present study\, we have observed for the first time\, connected pairs of
  TCs and VB interneurons (VBin) as well as VBins with other VBins\, the la
 tter providing a source of disinhibition. We investigated this newfound mi
 crocircuitry further to infer the functionality of observed circuit motifs
 . Thus\, we have found that VB interneurons enrich the somatosensory thala
 mus with a level of complexity that was previously unknown.\n 
LOCATION:Online
STATUS:CONFIRMED
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