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SUMMARY:BMI Progress Reports - ZOOM // Dr. La Manno's Lab - Gioele La Mann
 o: A comprehensive map of nervous system development from gastrulation to 
 birth
DTSTART:20201014T121500
DTEND:20201014T130000
DTSTAMP:20260510T022926Z
UID:ce279546fdba4b3283326e1adb5ae73cfcd9ba109ae3e75ef2093261
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gioele La Manno\nThe mammalian brain develops through a comple
 x interplay of spatial cues generated by diffusible morphogens\, cell-cell
  interactions\, and intrinsic genetic programs that result in the generati
 on of likely more than a thousand distinct cell types. Therefore\, a compl
 ete understanding of mammalian brain development requires systematic mappi
 ng of cell states covering the entire relevant spatiotemporal range. I wil
 l talk about a comprehensive single-cell transcriptome atlas of mouse brai
 n development spanning from gastrulation to birth we erectly reported. We
  identified almost a thousand distinct cellular states\, including the ini
 tial emergence of the neuroepithelium\, a rich set of region-spe- cific se
 condary organizers and a complete developmental program for the functional
  elements of the brain and its enclosing membranes. I am going to show how
  we used the atlas to directly test the hypothesis that human glioblastoma
  reflects a return to a developmental cell state. In agreement\, most aneu
 ploid tumor cells matched embryonic rather than adult types\, while karyot
 ypically normal cells predominantly matched adult immune cell types.\n 
LOCATION:Online https://epfl.zoom.us/meeting/register/tJIvceqhqjMpGtGHWZQ7
 gmu96_V8MXMdgpnX
STATUS:CONFIRMED
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