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SUMMARY:BMI Progress Reports 2020 // Prof. McCabe's Lab - Jamshid Asadzade
 h : Glutamate receptors interact with transcription factors to regulate sy
 naptic scaling
DTSTART:20201209T131500
DTEND:20201209T140000
DTSTAMP:20260407T162508Z
UID:ca42a233c2870401849d2d134481c5f5fc697b33a0c3bfa28e255c21
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jamshid Asadzadeh\, Laboratory of Neural Genetics and Disease\
 , BMI\nSynaptic scaling\, where postsynaptic receptor levels or compositio
 n are altered in response to changes in network activity\, is an important
  adaptive mechanism to maintain circuit homeostasis. Here we describe a no
 vel scaling activity of glutamate receptors in Drosophila motor synapses. 
 Surprisingly\, we demonstrate that regulation of this scaling process empl
 oys direct activity-dependent molecular interaction of glutamate receptors
  with postsynaptic transcription factors. Our results reveal a novel mecha
 nism for activity-dependent gene regulation\, where changes in synaptic ac
 tivity can immediately influence neuronal transcription factor function\, 
 without the requirement for intermediary signal transduction cascades. \n
 \n 
LOCATION:Online https://epfl.zoom.us/meeting/register/tJIvceqhqjMpGtGHWZQ7
 gmu96_V8MXMdgpnX
STATUS:CONFIRMED
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