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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Cancelled event - IMX Seminar Series - An Instagram View of the Na
 noworld
DTSTART:20200525T131500
DTEND:20200525T141500
DTSTAMP:20260506T044831Z
UID:bb34378f825288951caa8fb1ad121e3a8864efd3855881e4300328cf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Deb Kelly\, Penn State Cancer Institute\, USA\nDeparment
  of Biomedical Engineering\; Center for Structural Oncology\, Pennsylvania
  State University\, University Park PA 16802\, USA\n\nBiomedical research 
 improves our understanding of human health and disease through the develop
 ment of new technologies. High-resolution imaging is one technology that i
 s transforming our view of the nanoworld – permitting us to study cells 
 and molecules in exquisite detail. Structural information of dynamic compo
 nents\, however\, reveals only an instant of their complex narrative.\n\nR
 ecent advances in the production of materials such as graphene and silicon
  nitride provide new opportunities for EM imaging in real-time. We use the
 se materials to create environmental chambers and perform experiments in s
 itu\, or “inside”\, the EM column. Together\, with microfluidic techno
 logy\, we can now view biological processes in a native liquid environment
  at the nanoscale. Other recent applications of in situ imaging include re
 al-time recordings of nanoparticle therapies interacting with cancer stem 
 cells and changes in the molecular intricacies of viral pathogens. These r
 esults complement our ongoing cryo-EM studies on tumor suppressor proteins
  as we strive to analyze molecular events with high spatial and temporal r
 esolution.\n\nAcknowledgements: This work was supported by funding from th
 e National Institutes of Health and the National Cancer Institute [R01CA19
 3578\, R01CA227261\, and R01CA219700 to D.F.K.].\nBio: Deb Kelly completed
  her PhD in Molecular Biophysics at Florida State University and her post
 -doctoral training in Structural Biology at Harvard Medical School. During
  these pursuits\, she developed technical breakthroughs in the field of c
 ryo-EM that are now being used by the in situ TEM community. As interest i
 n situ TEM has skyrocketed in recent years\, the Kelly team has been on th
 e leading-edge of adapting this technology for biomedical applications\, i
 n particular cancer research. Dr. Kelly is currently a professor of Biomed
 ical Engineering at the Pennsylvania State University\, where the holds th
 e Lloyd and Dottie Foehr Huck Chair in Molecular Biophysics and directs th
 e Center for Structural Oncology (CSO). The CSO focuses on combating the m
 olecular culprits that fuel human cancer while revealing the hidden enemie
 s that cancer cells use to outsmart modern medicine. 
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
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