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SUMMARY:Glimpses of Gut Microbes in their Physical World
DTSTART:20200124T090000
DTEND:20200124T100000
DTSTAMP:20260917T070532Z
UID:3cef0e99b420c72807124ccd4ecf335bab8875b5de3a03c8d9977bb5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Raghuveer Parthasarathy received his undergraduate degree in P
 hysics from the University of California at Berkeley and a Ph.D. in Physic
 s from the University of Chicago\, where his dissertation work examined se
 lf-assembled nanocrystal arrays. He then returned to Berkeley as a Miller 
 Research Fellow and postdoctoral fellow in the Department of Chemistry\, e
 xploring lipid and protein membranes. In 2006 he joined the faculty at the
  University of Oregon\, where he is presently a Professor of Physics. His 
 research focuses on biophysics\, especially the structure and dynamics of 
 multicellular communities\, which his lab explores using techniques such a
 s three-dimensional microscopy. His teaching primarily involves courses fo
 r non-science majors\, such as a “biophysics for non-scientists” class
 .\n\nIn any ecosystem\, the physical structure of the landscape and the ac
 tivities of its resident organisms influence one another. This holds in th
 e vertebrate gut as well\, where legions of microbes cooperate\, compete\,
  and influence the health of their hosts. In intestinal ecosystems\, howev
 er\, we know little about the spatial structure\, bacterial behaviors\, an
 d physical forces present\, severely limiting our ability to understand an
 d eventually engineer the gut flora. To address this\, my lab applies ligh
 t sheet fluorescence microscopy\, an optical technique that enables high-s
 peed\, high-resolution three-dimensional imaging\, to larval zebrafish\, a
  model organism that enables a high degree of experimental control. I will
  describe this approach and experiments that have revealed how bacteria ca
 n manipulate intestinal mechanics to facilitate invasion\, how antibiotics
  can cause collapses in gut populations in a manner reminiscent of gelatio
 n transitions in soft matter physics\, and more. In all these cases\, the 
 physical structure of microbial groups emerges as a major determinant of t
 heir dynamics.\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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