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SUMMARY:[ U.S. CDMRP - ALS Therapeutic Development Award | Research Fundin
 g ]
DTSTART;VALUE=DATE:20200327
DTSTAMP:20260511T164300Z
UID:d84e7d9437b871a5f04a8263153108b7801cf60fc10a9990d08a62fa
CATEGORIES:Call for proposal
DESCRIPTION:Aim: Through the Congressionally Directed Medical Research Pro
 gram (CDMRP)\, the Department of Defense is announcing the Amyotrophic Lat
 eral Sclerosis (ALS) Research Program Therapeutic Development Award. This 
 Award supports research ranging from validation of therapeutic leads throu
 gh U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-
 enabling studies. The proposed studies are expected to be empirical in nat
 ure and product-driven. Preliminary data are required\, including efficacy
  in at least one ALS-relevant model system with a lead molecule/class of c
 ompounds. The availability of validated biomarkers or biomarker developmen
 t/characterization\, in parallel to the main therapeutic effort and for us
 e in eventual clinical trials\, is a critical component of the FY20 ALSRP 
 Therapeutic Development Award. Applicants with limited ALS experience are 
 strongly encouraged to include collaborators with substantial expertise in
  the relevant ALS model systems\, endpoints\, and pathophysiology.\n\nBiom
 arker development and/or characterization (if not already validated)\, in 
 parallel to the main therapeutic effort\, is a critical component of the F
 Y20 ALSRP Therapeutic Development Award. Efforts may include development/c
 haracterization of target engagement biomarkers\, pharmacodynamic biomarke
 rs to measure the biological effect of an investigational therapeutic\, an
 d/or predictive/cohort-selective biomarkers that indicate whether a specif
 ic therapy will be effective in an individual patient or patient subgroup.
 \n\nFunding:        max. $1’000’000\n\nDuration:       3 y
 ears\n\nEligibility: Applicants from international organizations or instit
 utions are eligible to apply\, and there are no citizenship restrictions. 
 Applicants must be independent investigators\, but can come from any acade
 mic level.\n\nHow to Apply: Pre-applications are submitted through the eBR
 AP platform. They should contain contact information\, a list of collabora
 tors and key personnel\, a preproposal narrative\, and supporting document
 ation as suggested on the platform. Full applications (by invitation) will
  be made via a Grants.gov workspace. Full application packages can be down
 loaded from Grants.gov at any time.\n\nPre-Application Deadline: 27 March 
 2020\, 5:00 p.m.\nFull Application Deadline: 23 July 2020\, 11:59 p.m. EST
 \n\nGrants.gov Funding Opportunity Number: W81XWH-20-ALSRP-TDA\n\nFurther 
 information\n\n	To see the program announcement\, navigate to the search p
 age on Grants.gov and search for the Opportunity Number W81XWH-20-ALSRP-TD
 A\n	For questions about the eBRAP or Grants.gov platforms\, contact the Re
 search Office.\n
LOCATION:
STATUS:CONFIRMED
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