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SUMMARY:Metabolomic analyses of Drosophila models for human metabolic diso
 rders
DTSTART:20120911T160000
DTEND:20120911T170000
DTSTAMP:20260502T060023Z
UID:52cd136905807a50eeaafa512558fc83850750df94abe77d9a8b3107
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Toshiro Aigaki\nDepartment of Biological Sciences\, Toky
 o Metropolitan University\nThe fruit fly\, Drosophila melanogaster shares 
 many genes with humans: approximately 75% of diseases-related genes in hum
 ans have orthologs in the fly\, and it has been used as a model system to 
 study molecular and genetic bases of human diseases. However\, relatively 
 little has been studied for mutations in genes involved in energy metaboli
 sm\, whose defects may cause metabolic disorders\, such as diabetes\, hear
 t disease\, fatty liver\, and several cancers. To facilitate the understan
 ding of molecular bases of these diseases\, we are currently generating an
 d analyzing loss-of-function mutations in metabolic genes in Drosophila. 
  We search for such mutations among the collection of transposon insertion
  lines\, or generate knockout mutant by gene-targeting. To characterize th
 e mutants\, we used liquid chromatography mass spectrometry (LC-MS)\, whic
 h is a powerful tool for metabolomics.  I will present the phenotypic and
  metabolomic properties of Drosophila mutants\, which showed the symptoms 
 of lipoic acid synthase (LIAS) deficiency and mitochondrial trifunctional 
 protein (MTP) deficiency in humans. 
LOCATION:AI1153
STATUS:CONFIRMED
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