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SUMMARY:Host cell environments and antibiotic efficacy in tuberculosis
DTSTART:20200218T121500
DTSTAMP:20260509T123501Z
UID:679ff585456c68c4aeee87a630b1d9a89b23b7948cfc8cd56b3284c6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Maximiliano G. Gutierrez\, The Francis Crick Institute\, Londo
 n\, UK\nTo cause disease and disseminate to other hosts\, M. tuberculosis 
 needs to replicate within human cells. Work in the last decades have shed 
 light into some aspects of tuberculosis pathogenesis\, however\, we still 
 do not understand how M. tuberculosis manages to survive within eukaryotic
  cells and why some cells are able to eradicate this lethal pathogen. This
  surprising gap in knowledge is in part due to the lack of appropriate ima
 ging technologies that have precluded comprehensive understanding of the f
 undamental biology that underpins M. tuberculosis-host cell interactions. 
 Our research focuses on the fundamental molecular and cellular mechanisms 
 that regulate the interactions between M. tuberculosis and host cells. We 
 aim to dissect the host cell factors that contribute to M. tuberculosis co
 ntrol as well as the M. tuberculosis factors that this pathogen uses to hi
 ghjack host cells. To this end\, we use a variety of cutting-edge imaging 
 approaches and model systems. In this seminar\, I will present some recent
  data from our group regarding the environments where M. tuberculosis surv
 ives in human cells and the barriers that these environments represent for
  therapy.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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