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SUMMARY:The revolution will be compartmentalized: Miniaturized chemical li
 brary synthesis and microfluidic screening technology for distributed drug
  discovery
DTSTART:20200210T161500
DTEND:20200210T171500
DTSTAMP:20260406T063950Z
UID:96bc62b68e388df5a3131f0db72faebb0c8ceba715c4b4768fbcc2b4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Brian Paegel\, UC Irvine\nThe NIH Molecular Libraries Pr
 ogram was founded to translate the discoveries of the Human Genome Project
  into therapeutics through a network of high-throughput screening centers.
  A decade of discovery produced hundreds of probes — highly selective sm
 all molecules that modulate cellular function — but centralized compound
  screening bears the same cost and infrastructure burdens of millennial DN
 A sequencing centers\, which has limited access to the technology and\, mo
 re significantly\, the rate of small molecule discovery. We are building a
  distributable drug discovery platform analogous to next-generation DNA se
 quencing based on ultra-miniaturized DNA-encoded solid-phase compound libr
 aries and microfluidic instrumentation for scalable\, automated screening.
  I will overview chemical synthesis and microfluidic screening technology 
 development efforts and describe their application in a collaboration with
  Roche Pharma R&D to discover drug-like ligands of two clinically relevant
  targets implicated in idiopathic pulmonary fibrosis and several cancers. 
 Looking toward the future\, we are exploring approaches that directly tran
 slate genomic sequence into bioactive chemical probes toward fulfilling th
 e originally promised pay dirt of the Human Genome Project.\n 
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CANCELLED
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