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SUMMARY:Unusual interfaces and anomalous glassy behavior in biological mat
 ter
DTSTART:20200213T140000
DTEND:20200213T153000
DTSTAMP:20260415T024316Z
UID:3280a3423175cb176bcf3a0f51e2a6baf75c7390d21e4766d4c2a655
CATEGORIES:Conferences - Seminars
DESCRIPTION:Daniel Sussman\nWhat can we learn about dense biological tissu
 e by viewing it as a soft\, active material? The mechanical and dynamical 
 properties of dense collections of cells help govern processes ranging fro
 m wound healing to embryonic development to cancer progression\, and an ou
 tstanding challenge is developing tractable models that can predict and ex
 plain the amazing variety of complex phenomena that even simple cellular s
 ystems can exhibit. Recent experiments have shown\, for example\, that man
 y tissues lie close to a collective rigidity transition\, and I will discu
 ss how simple coarse-grained models of dense\, disordered tissue can suppo
 rt unusual forms of low-temperature rigidity. I will then show that these 
 models exhibit anomalous interfacial properties where different measuremen
 ts of the surface tension between two tissues types can differ by orders o
 f magnitude. This departure from equilibrium behavior can be understood as
  a generic consequence of certain topological features of the cell-cell in
 teractions\, and I will discuss the potential relevance of this mechanism 
 for both biological processes (such as cell sorting and compartmentalizati
 on) and for designing new materials with exotic bulk and boundary behavior
 .\n 
LOCATION:BSP 727 https://plan.epfl.ch/?room==BSP%20727
STATUS:CONFIRMED
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