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SUMMARY:Synthetic and single-molecule exploration of the dynamic chromatin
  landscape
DTSTART:20200211T121500
DTSTAMP:20260503T040041Z
UID:a5273de03ce630d6bae3f5fa677bdd58a811a4389d8d2a1ad9cf19e0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Beat Fierz\, Laboratory of Biophysical Chemistry of Macromolec
 ules\, Basic Sciences\, EPFL\nThe organization of the eukaryotic genome in
 to chromatin is integral to genome regulation. Chromatin structure and dyn
 amics\, modulated by histone post-translational modifications (PTMs) as we
 ll as architectural proteins\, dictate DNA access for transcription factor
 s and the gene expression machinery. Due to the fundamental role of chroma
 tin\, a molecular and dynamic understanding of this nucleoprotein complex 
 is required.\n\nWe dissect chromatin signaling on the single-molecule scal
 e\, combining chemical biology approaches and mechanistic biophysics. In p
 articular\, we have developed single-molecule fluorescence approaches to d
 irectly observe chromatin dynamics as well as to monitor protein interacti
 on dynamics with modified chromatin fibers in real-time. Together with che
 mical approaches to reconstitute differentially modified chromatin\, these
  methods allowed us to reveal fundamental mechanisms in gene repression by
  the polycomb machinery\, and gene activation by pioneer transcription fac
 tors. Together\, our results provide a mechanistic view of how chromatin s
 tructure and dynamics are regulated by chromatin PTMs and protein effector
 s to establish repressive or active architectures\, thereby controlling ge
 ne expression.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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