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SUMMARY:How Environmental Bacteria Explore the Chemical Landscape and Inve
 nt New Reactions
DTSTART:20200210T121500
DTSTAMP:20260512T050115Z
UID:c4fc168f1baf81d05e37720a89f661e5d1a6a9d578dfdb8a41056a19
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Víctor de Lorenzo\, Spanish National Research Council -
  CSIC\, Madrid (E)\nBIOENGINEERING SEMINAR\n(sandwiches served)\n\nAbstrac
 t:\nThe still-evolving 2\,4-dinitrotoluene (DNT) pathway of Burkholderia 
 cepacia R34 has been studied as a case of emergence of new metabolic capa
 bilities in environmental bacteria. The DNT route originated from a precu
 rsor naphthalene degradation pathway and the first enzyme (DNT dioxygenase
 ) maintains significant activity towards its earlier substrate. Inspectio
 n of in vivo reactions indicates that reactive oxygen species (ROS) gene
 rated by the faulty (i.e. uncoupled) reaction of the precursor enzymes wi
 th DNT elicit genetic diversification. Artificially decreasing the intrace
 llular pool of NAD(P)H caused DNT+ cells to acquire a high genetic-divers
 ification regime. These observations provide a view of metabolic evolution
  as a sort of heterotic computing in which the problem is embodied in th
 e physicochemical frame of the cell and the exploration of the solution s
 pace is pushed by its endogenous dynamics. On this basis\, it is plausible
  that some members of a given microbial community are prone to innovate t
 heir metabolic capacities much faster than others while the rest may benef
 it from such innovation through horizontal gene transfer.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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