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SUMMARY:Tissue tectonics and the emergence of pattern during complex morph
 ogenesis
DTSTART:20200302T140000
DTEND:20200302T150000
DTSTAMP:20261005T052832Z
UID:12d1ee8f660f16a413ba470f0b217c34a0d8d70251a4124c5ca59566
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Ben Steventon\, from Department of Genetics\, University o
 f Cambridge\, UK\nAbstract:\n\n“As cells proceed through development\, i
 nformation contained in the genome is expressed in a context-dependent man
 ner. This must be regulated precisely in both space and time to generate p
 atterns of gene expression that set-up the spatial coordinates of tissue a
 nd organ primordia that build the embryo. Our current understanding of pat
 tern formation relies on the concept of positional information\, the idea 
 that cells receive instructive signals that impart a spatial coordinate sy
 stem to generate pattern. While this model works very well in static cell 
 populations with minimal cell rearrangement\, it becomes challenging when 
 considering dynamic morphogenetic processes such as gastrulation. Furtherm
 ore\, pattern formation in gastrulation is highly flexible to alterations 
 in the size\, scale and spatial rearrangement of cells in both experimenta
 l and evolutionary situations. I will introduce two new concepts to the fi
 eld of developmental genetics that will help resolve these long-standing p
 roblems of pattern regulation\, evolvability and self-organisation. Firstl
 y\, tissue tectonics emphasises the role that multi-tissue interactions pl
 ay in relaying information from changes at the organ and organism level to
  the regulation of gene regulatory networks (GRNs) at the cell level. Seco
 ndly\, pattern emergence considers how extracellular signals act to contro
 l the dynamics of autonomous GRN activity\, rather than as instructive sig
 nals to direct cell fate transitions. In this sense\, pattern formation sh
 ould not be seen as a downstream output of organisers and their responding
  tissues\, but rather as an emergent property of their dynamic interaction
 . These concepts will be illuminated with examples from our recent work on
  explants from early zebrafish embryos and the comparative analysis of neu
 romesodermal progenitors”\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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