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SUMMARY:Harnessing massive peptide libraries to explore the inhibition of 
 epigenetic drug targets
DTSTART:20200630T160000
DTEND:20200630T174500
DTSTAMP:20260508T164308Z
UID:0f7b9981d9a2a497e113cb441591227ecd260d913fc0c9f92dfd39b6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Louise Walport\nEpigenetic regulators finely tune gene r
 egulation in a healthy cell\, but their misregulation frequently contribut
 es to disease. In many cases\, however\, achieving selective inhibition ha
 s been challenging\, due to the presence of a multiple\, closely-related i
 soforms. Cyclic peptides are an emerging class of natural product-like dru
 gs with diverse structures that can easily be adapted to potently and sele
 ctively target any protein of interest. This talk will discuss the use of 
 the RaPID system\, a trillion member cyclic peptide discovery platform\, t
 o develop potent and selective modulators of two epigenetic drug targets: 
 the rheumatoid arthritis target\, PADI4\, and the cancer targets\, the BET
  bromodomains.
LOCATION:https://epfl.zoom.us/j/91953247264
STATUS:CONFIRMED
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