BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:New tools for the identification and analysis of glycans
DTSTART:20200305T171500
DTEND:20200305T191500
DTSTAMP:20260506T061818Z
UID:e2bf6c859e4030b5c5763b7068a54894ee605457a51c2fe306a2c0c4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. Thomas Rizzo\nGlycans\, which are biopolymers made u
 p of monosaccharide units linked by glycosidic bonds\, are ubiquitous in b
 iological systems. Because they decorate the surface of cells\, they play 
 a central role in virtually all cellular recognition processes and are dir
 ectly implicated in almost every major disease. Their structural character
 ization is thus of utmost importance. Unfortunately\, the isomeric complex
 ity of glycans presents severe challenges for mass-spectrometric determina
 tion of primary structure. This is complicated by the fact that their synt
 hesis is not template-driven as in the case of proteins. Thus\, most of th
 e powerful tools available for protein sequencing simply do not apply to g
 lycans.\nOver the last few years\, we have been developing new tools for a
 nalysing released glycans by combining ultrahigh-resolution ion mobility w
 ith cryogenic vibrational spectroscopy and mass spectrometry. Ion mobility
  is used to separate isomeric species\, and cryogenic IR spectra\, which a
 re extremely sensitive to the slightest differences in structure\, are the
 n used to identify them. The goal is to create a spectroscopic database of
  glycans and glycan fragments that can be used to rapidly identify them fr
 om a mixture.\nThis talk will demonstrate the variety of tools we have dev
 eloped to identify glycans for which standards are available as well as sc
 hemes to analyse the primary structure of unknown glycans.
LOCATION:BCH 2201 https://plan.epfl.ch/?room==BCH%202201
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR