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SUMMARY:TO BE RESCHEDULED (Covid-19 situation) - "Injectable Synthetic Bui
 lding Blocks to Regenerate Soft Anisotropic Tissues"
DTSTART:20200310T150000
DTEND:20200310T160000
DTSTAMP:20260531T010816Z
UID:388d58559f426633a9eb442862cb270ef9479ddff372402fc4c02eeb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Laura De Laporte\, DWI – Leibniz Institute for Interac
 tive Materials\, RWTH University\, Aachen (D)\nBIOENGINEERING SEMINAR\n\nA
 bstract:\nWe apply polymeric molecular and nano- to micron-scale building 
 blocks to assemble soft 3D biomaterials with anisotropic and dynamic prope
 rties. Microgels and fibers are produced by technologies based on fiber sp
 inning\, microfluidics\, and in-mold polymerization. To arrange the buildi
 ng blocks in a spatially controlled manner\, self-assembly mechanisms and 
 assembly by external magnetic fields are employed. For example\, the Aniso
 gel technology offers a solution to regenerate sensitive tissues with an o
 riented architecture\, which requires a low invasive therapy. It can be in
 jected as a liquid and structured in situ in a controlled manner with defi
 ned biochemical\, mechanical\, and structural parameters. Magnetoceptive\,
  anisometric microgels or short fibers are incorporated to create a unidir
 ectional structure. Cells and nerves grow in a linear manner and the fibro
 nectin produced by fibroblasts is aligned. Regenerated nerves are function
 al with spontaneous activity and electrical signals propagating along the 
 anisotropy axis of the material. Another developed platform is a thermores
 ponsive hydrogel system\, encapsulated with plasmonic gold-nanorods\, whic
 h actuates by oscillating light. This system elucidates how rapid hydrogel
  beating leads to a reduction in cell migration\, while enhancing focal ad
 hesions\, native production of extracellular matrix\, and nuclear transloc
 ation of mechanosensitive proteins\, depending on the amplitude and freque
 ncy of actuation.\n\nBio:\nLaura De Laporte combines engineering\, chemist
 ry and biology to design biomaterials that control and direct the interact
 ion with cells. She is a Chemical Engineer from Ghent\, where she got the 
 tissue engineering microbe. To follow her dream\, she did her PhD with Lon
 nie Shea at Northwestern University and engineered guiding implants for ne
 rve regeneration. At EPFL\, she learned about hydrogels in Jeffrey Hubbell
 ’s group during her post-doctoral research. Currently\, she is a Leibniz
  Professor at the RWTH University in Aachen\, Germany\, where she works on
  Advanced Biomedical Systems at the DWI-Leibniz Institute for Interactive 
 Materials. In the framework of the ERC Starting Grant Anisogel\, her team 
 designs low-invasive\, polymeric regenerative hydrogel therapies\, consist
 ing of nano –and micron-scale building blocks that orient after injectio
 n to repair anisotropic tissues. In addition\, dynamic hydrogels are creat
 ed to study mechanobiology.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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