BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Nectin-1: from receptor for herpes simplex virus to cell adhesion 
 and innate immunity
DTSTART:20200320T150000
DTSTAMP:20260509T024429Z
UID:e0c986e50231b0cb50c7aced980a1b0f134f40b57835047e427a09cb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Claude Krummenacher\, College of Science & Mathematics\, Rowan
  University\, Glassboro\, New Jersey\, USA\nNectins form a family of cell 
 adhesion molecules that also serve as receptors for numerous human viruses
  (incl. herpes simplex virus (HSV)\, measles virus\, poliovirus). My work 
 has focused on the role of nectin-1 in entry of HSV into cells.  This led
  to the current molecular model of activation of viral glycoproteins upon 
 nectin-1 binding. Structural and functional data showed that the viral lig
 and (glycoprotein D) binds a functional site of nectin-1\, thereby indicat
 ing that the virus will interfere with the natural functions of nectin-1\,
  possibly to its own advantage. Therefore\, more recently\, I focused on u
 nderstanding how HSV affects the natural roles of nectin-1 in cell-cell re
 cognition through direct competition with ligands and induction of down-re
 gulation. The recent discovery that nectins are involved in regulating the
  Natural Killer (NK) cell activation during the innate immune response als
 o led us to investigate the role of nectin-1 as a ligand for NK cell recep
 tors and adhesion molecules. This is leading us to develop a model of how 
 HSV affect nectin-1 function to spread and potentially avoid the NK cell i
 mmune response.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CANCELLED
END:VEVENT
END:VCALENDAR