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SUMMARY:Evolutionary adaptation to DNA replication stress
DTSTART:20200306T100000
DTEND:20200306T110000
DTSTAMP:20260504T230109Z
UID:1ec4af1890faed41f7efb3b45a1945b9ca635b9bece1cefed9ad154b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Marco Fumasoni - Harvard University\nMany biological features 
 are conserved and thus considered to be resistant to evolutionary change. 
 While rapid genetic adaptation following the removal of conserved genes ha
 s been observed\, we often lack a mechanistic understanding of how adaptat
 ion happens. We used the budding yeast\, /Saccharomyces cerevisiae/\, to i
 nvestigate the evolutionary plasticity of chromosome metabolism\, a networ
 k of evolutionary conserved modules. We experimentally evolved cells const
 itutively experiencing DNA replication stress caused by the absence of Ctf
 4\, a protein that coordinates the enzymatic activities at replication for
 ks. Parallel populations adapted to replication stress\, over 1000 generat
 ions\, by acquiring multiple\, concerted mutations. These mutations altere
 d conserved features of two chromosome metabolism modules\, DNA replicatio
 n and sister chromatid cohesion\, and inactivated a third\, the DNA damage
  checkpoint. The selected mutations define a functionally reproducible evo
 lutionary trajectory. We suggest that the evolutionary plasticity of chrom
 osome metabolism has implications for genome evolution in natural populati
 ons and cancer.
LOCATION:BSP 407 https://plan.epfl.ch/?room==BSP%20407
STATUS:CANCELLED
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