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SUMMARY:MEchanics GAthering -MEGA- Seminar: Talk1 - Granular hydrogels as 
 novel bioinks for 3D printing of artificial soft tissues\; Talk2 - Immobil
 izing different types of drops in microfluidic devices
DTSTART:20200312T161500
DTEND:20200312T173000
DTSTAMP:20260925T100701Z
UID:e7fc1fc7cd6e0171ef3384a27cfcd3bc4de61ef8a5573e9b3a2cb998
CATEGORIES:Conferences - Seminars
DESCRIPTION:Matteo Hirsch & Mickael Kessler\, Soft Materials Laboratory (S
 MaL)\, EPFL\nGranular hydrogels as novel bioinks for 3D printing of artifi
 cial soft tissues\, by Matteo Hirsch (SMaL\, EPFL)\n\nHydrogels are among
  the first biomaterials expressly designed for their use in biomedicine. H
 owever\, state-of-the-art applications of hydrogels are severely limited b
 ecause they are typically either too soft or too brittle such that they ca
 nnot be used for load-bearing applications. At present\, synthetic hydroge
 ls are still far from reaching mechanical performances similar to that of 
 their biological counterparts. One of the main reasons behind this differe
 nce is their poor internal arrangement. Indeed\, nature is able to fabrica
 te soft biological tissues encompassing highly ordered\, hierarchical stru
 ctures with locally varying compositions. Inspired by nature\, we propose 
 to use microgels as building blocks for the fabrication of 3D printed gran
 ular materials. Moreover\, we investigate the effect of different processi
 ng parameters on the rheological behavior of jammed microgel solutions and
  on the mechanical performance of granular hydrogels.\n\nImmobilizing diff
 erent types of drops in microfluidic devices\, by Mickael Kessler (SMaL\, 
 EPFL)\n\nMany natural materials display unique mechanical properties that 
 are\, at least in parts\, a result of the locally varying compositions of 
 these materials. (1) Bio-inspired materials usually cannot reach similar s
 ets of mechanical properties than their natural counterparts. A contributi
 ng reason for this difference is that they typically possess homogeneous c
 ompositions. A possibility to fabricate soft\, structured materials with l
 ocally varying compositions is the use of reagent-loaded drops as building
  blocks. (2) In my talk\, I will present a microfluidic device that allows
  immobilization of drops loaded with different reagents at well-defined po
 sitions. Thereby\, this device offers possibilities to control the local c
 omposition of the resulting materials. I will show how we can vary the tra
 pping force of such traps to achieve a selective immobilization of only on
 e type of drops. I will further present a mathematical model that predicts
  the trapping strength of traps depending on their geometry\, which facili
 tates the design of such devices. To conclude\, I will demonstrate an exam
 ple of how immobilized drops can be transformed into soft materials with l
 ocally varying composition. This technology offers new possibilities to de
 sign bio-inspired structured hydrogels with improved mechanical properties
 .\n(1) Harrington\, M. J.\, Masic\, A.\, Holten-Andersen\, N.\, Waite\,
  J. H. & Fratzl\, P. Iron-clad fibers: a metal-based biological strategy f
 or hard flexible coatings. Science 328\, 216–20 (2010).\n(2) Priemel\
 , T.\, Degtyar\, E.\, Dean\, M. N. & Harrington\, M. J. Rapid self-assembl
 y of complex biomolecular architectures during mussel byssus biofabricatio
 n. Nat. Commun. 8\, 14539 (2017).\n(3) Brakke\, Kenneth A. 1992. The surfa
 ce evolver. Experiment. Math. 1\n(4) Dangla\, R.\, Lee\, S. & Baroud\, C. 
 N. Trapping Microfluidic Drops in Wells of Surface Energy. Phys. Rev. Lett
 . 107\, 124501 (2011).
LOCATION:MED 2 2423 https://plan.epfl.ch/?room==MED%202%202423
STATUS:CANCELLED
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