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SUMMARY:[ Alzheimer’s Drug Discovery Foundation – Drug Development Pro
 gram| Research Funding ]
DTSTART;VALUE=DATE:20200710
DTSTAMP:20260916T043720Z
UID:8baf261fee2d5a4fadf76f5331892bc539eebfd967ef171732ae1558
CATEGORIES:Call for proposal
DESCRIPTION:Aim:  The goal of this request for proposals (RFP) is to deve
 lop therapeutics for Alzheimer's disease and related dementias. This RFP f
 ocuses on building preclinical evidence in animal models and on advancing 
 lead molecules to the clinical candidate selection stage. The proposed stu
 dies should have a high probability of reaching IND-enabling studies withi
 n two years.\n\nSpecifically\, the Drug Development RFP supports:\n\n	Prec
 linical pharmacokinetics\, pharmacodynamics\, target engagement\, and prel
 iminary rodent tolerability\n	In vivo efficacy or proof-of-concept studies
 \n\n\nThe ADDF is interested in small molecules and biologics (e.g. antibo
 dies\, peptides\, gene therapies). Both novel programs and repurposing/rep
 ositioning of approved or clinically safe therapies from other disease ind
 ications are appropriate for this RFP.\n\nCurrent target areas of interest
  include:\n\n	Epigenetics\n	Inflammation\n	Mitochondria & metabolic functi
 on\n	Neuroprotection\n	Proteostasis\n	Synaptic activity and neurotransmitt
 ers\n	Vascular function\n	Other aging target (e.g. senescent cells)\n	Othe
 r novel targets or pathways that are supported by compelling evidence demo
 nstrating a rational biological connection to the disease process\n\n\nFun
 ding:        max. $600\,000\n\nDuration:      1 year\n\nEligibil
 ity: Funding is open to researchers and clinicians worldwide at academic m
 edical centers and universities or nonprofits. Industry partnerships are e
 ncouraged.\n\nHow to Apply: Deadlines for proposal submissions occur quart
 erly. Applications are reviewed in a two-step process: Letters of Intent (
 LOI) are the first step. ADDF’s science team will evaluate LOIs to deter
 mine whether the proposed project is consistent with the ADDF's mission an
 d funding priorities. LOI decisions will be sent within three weeks of sub
 mission. Step 2 is an invited full proposal\, which should include a detai
 led project narrative\, budget and justification\, and biographical inform
 ation.  When formulating the budget\, note that the following costs are n
 ot covered: Indirect costs/Overhead\, Publication costs\, Equipment\, and 
 Travel.\n\nSummer Deadlines:            10-July-20 (letter of i
 ntent)\n                                 
                07-Aug-20 (full proposal\, by invitation)\n\n
 Autumn Deadlines:            09-Oct-20 (letter of intent)\n  
                                      
          06-Nov-20 (full proposal\, by invitation)\n\nFurther info
 rmation\n\n\n	More information about the program is available here\n	Detai
 led application instructions are here\n	The application portal can be foun
 d here\n	For any other questions\, please contact the Research Office\n
LOCATION:
STATUS:CONFIRMED
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