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SUMMARY:'Mapping biochemical drivers of phenotypic change'
DTSTART:20200701T161500
DTEND:20200701T173000
DTSTAMP:20260415T024342Z
UID:8803624038218ac02f20c24e2be4cec98cbbd605ab72992bcbabf140
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Daniel F. Jarosz\, Associate Professor of Chemical and 
 Systems Biology and of Developmental Biology at Stanford University\, USA.
 \nHow do some biological systems remain unaltered for long periods\, where
 as others diversify rapidly? This paradox lies at the heart of how neurons
  can be killed by a single aggregation-prone protein\, how cancers tolerat
 e extreme mutation burden\, and how a genetic variant can have devastating
  consequences in only some individuals. Daniel F. Jarosz\, Associate Profe
 ssor of Chemical and Systems Biology and of Developmental Biology at Stanf
 ord University\, employs approaches ranging from chemical biology to syste
 m’s level quantitative genetics and use models as diverse as baker’s y
 east and the African killifish. \n\nAbout the talk\nSurvival in changing 
 environments requires the acquisition of new heritable traits. However\,
  mechanisms that safeguard the fidelity of DNA replication often limit t
 he source of such novelty to relatively modest changes in the genetic cod
 e. Thus\, the acquisition of new forms and functions is thought to be driv
 en by rare variants that occur at random\, and are enriched during times o
 f stress. The Jarosz lab has begun to study an intriguingalternative hypot
 hesis: that intrinsic links between protein folding and virtually every bi
 ological trait provide multiple avenues through which environmental stress
  can directly elicit heritable variation that drives evolution\, disease\,
  and development.\n\nThe lab aims to identify and characterize these mecha
 nisms at the molecular level\, integrating their findings to gain insight 
 into the interplay among genetic variation\, phenotypic diversity\, and en
 vironmental fluctuations in complex cellular systems. Much of their work c
 enters on the specific influence of molecular chaperones\, proteins that h
 elp other proteins fold. Other projects focus on the induction of epigenet
 ic variation that can be passed from one generation to another via self-pe
 rpetuating changes in protein conformation.\n\nTheir work employs multidi
 sciplinary approaches including biochemistry\, genome-scale analyses\, hi
 gh-throughput screening methodologies\, live cell imaging\, microfluidics\
 , and quantitative genetic techniques. Ultimately they seek to not only to
  understand mechanisms that link environmental stress to the acquisition o
 f biological novelty\, but also to identify means of manipulating them for
  therapeutic benefit and harnessing their power to engineer synthetic sign
 aling networks.\n\nDr. Jarosz is an Associate Professor of Chemical and S
 ystems Biology and of Developmental Biology at Stanford University. He is 
 also a fellow of ChEM-H and a member of the Stanford Cancer Institute\, St
 anford Neurosciences Institute\, and Bio-X. Dan received his B.S. in Chemi
 stry from the University of Washington\, then moved to MIT to obtain a PhD
  in Biochemistry\, where his thesis work established the function of a low
 -fidelity DNA polymerase with roles in cancer and infectious disease\, and
  identified means through which its activity is regulated in normal biolog
 y and disease states.\n\nTo join this event\, online registration is com
 pulsory.\nDeadline to register: June 26th
LOCATION:
STATUS:CONFIRMED
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